Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
BMC Ophthalmol. 2022 May 23;22(1):234. doi: 10.1186/s12886-022-02443-6.
To compare the quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TPRK) and off-flap epipolis-laser in situ keratomileusis (Epi-LASIK) in moderate to high myopia.
In this prospective self-control study, we included patients with moderate to high myopia who were randomized to undergo TPRK in one eye and Epi-LASIK in the other eye. Twelve-month follow-up results for visual acuity, refraction, ocular high-order aberrations, contrast sensitivity, postoperative pain, epithelial healing, and haze grade were assessed.
A total of 64 eyes (32 patients) were enrolled in the study. More eyes completed re-epithelialization in the TPRK group than in the Off-flap Epi-LASIK group 3-4 days postoperatively, while all eyes completed re-epithelialization by 7 days. More eyes achieved a visual acuity (both UDVA and CDVA) of better than 20/20 in the TPRK group than in the Off-flap Epi-LASIK group. The ±0.50 D predictability for correction of the spherical equivalent (SE) was higher in the eyes of the TPRK group (91%) than in those of the off-flap Epi-LASIK group (80%) 12 months after surgery. No significant differences in ocular aberrations, including coma, spherical, and trefoil, were found between the two groups at 12 months. There were also no significant differences in visual acuity, contrast sensitivity, pain, and haze grading between the two groups.
Both TPRK and off-flap Epi-LASIK are safe, effective, and predictable treatments for moderate to high myopia with comparable surgical outcomes.
This study was retrospectively registered on ClinicalTrial.gov ( NCT05060094 , 17/09/2021).
比较单步经上皮准分子激光角膜切削术（TPRK）和瓣下准分子激光角膜原位磨镶术（Epi-LASIK）治疗中高度近视的定量和定性光学效果。
本前瞻性自身对照研究纳入了中高度近视患者，他们被随机分配到一只眼接受 TPRK 治疗，另一只眼接受 Epi-LASIK 治疗。评估了 12 个月时的视力、屈光度、眼高阶像差、对比敏感度、术后疼痛、上皮愈合和混浊分级。
共有 64 只眼（32 例患者）纳入本研究。术后 3-4 天，TPRK 组中更多的眼完成了再上皮化，而所有的眼在 7 天内都完成了再上皮化。TPRK 组中有更多的眼达到了更好的视力（UDVA 和 CDVA），超过 20/20。TPRK 组（91%）的等效球镜（SE）矫正的±0.50 D 预测性优于瓣下 Epi-LASIK 组（80%），术后 12 个月。在 12 个月时，两组之间的眼像差，包括彗差、球差和三叶差，没有显著差异。两组之间的视力、对比敏感度、疼痛和混浊分级也没有显著差异。
TPRK 和瓣下 Epi-LASIK 都是治疗中高度近视的安全、有效和可预测的方法，具有相当的手术效果。
本研究在 ClinicalTrials.gov 上进行了回顾性注册（NCT05060094，2021 年 9 月 17 日）。
