植物源免疫调节剂。I：初步筛选。

Immunomodulating agents of plant origin. I: Preliminary screening.

作者信息

Atal C K, Sharma M L, Kaul A, Khajuria A

出版信息

J Ethnopharmacol. 1986 Nov;18(2):133-41. doi: 10.1016/0378-8741(86)90025-5.

Abstract

The immunobiological activity was investigated of certain medicinal plants widely used in the Ayurvedic and Unani systems of medicine for treatment of chronic infections and immunological disorders. The effect of an ethanolic extract of each drug was studied on delayed type hypersensitivity, humoral responses to sheep red blood cells, skin allograft rejection, and phagocytic activity of the reticuloendothelial system in mice. Picrorhiza kurroa was found to be a potent immunostimulant, stimulating both cell-mediated and humoral immunity. Tylophora indica, Aconitum heterophyllum and Holarrhena antidysenterica appeared to stimulate phagocytic function while inhibiting the humoral component of the immune system. Tinospora cordifolia and Ocimum gratissimum appeared to improve the phagocytic function without affecting the humoral or cell-mediated immune system. Hemidesmus indicus suppressed both the cell-mediated and humoral components of the immune system.

摘要

对阿育吠陀医学和尤那尼医学体系中广泛用于治疗慢性感染和免疫紊乱的某些药用植物的免疫生物学活性进行了研究。研究了每种药物的乙醇提取物对小鼠迟发型超敏反应、对绵羊红细胞的体液反应、皮肤同种异体移植排斥反应以及网状内皮系统吞噬活性的影响。发现胡黄连是一种有效的免疫刺激剂，可刺激细胞介导免疫和体液免疫。印度娃儿藤、异叶乌头和止泻木似乎在刺激吞噬功能的同时抑制免疫系统的体液成分。心叶地锦和罗勒似乎在不影响体液或细胞介导免疫系统的情况下改善吞噬功能。印度牛弥菜抑制免疫系统的细胞介导和体液成分。