植物化学分析及沙拐枣对胰腺α-淀粉酶和β-葡萄糖苷酶的抑制作用。
Phytochemical analysis and inhibitory effects of Calligonum polygonoides on pancreatic α-amylase and β-glucosidase enzymes.
机构信息
Department of Biotechnology, Faculty of Biological Sciences, University of Science & Technology, Bannu 28100, KPK-Pakistan.
Department of Botany, Faculty of Biological Sciences, University of Science & Technology, Bannu 28100, KPK-Pakistan.
出版信息
J Tradit Chin Med. 2022 Jun;42(3):426-431. doi: 10.19852/j.cnki.jtcm.2022.03.009.
OBJECTIVES
To estimate the existence of phyto-chemicals and then to determine the antidiabetic activity against α-amylase and β-glucosidase inhibition .
METHODS
The study was carried out by following standard procedures.
RESULTS
Phytochemicals analysis indicated the presence of different phytochemicals. The total phenolic content was 6.055 mg GAE/g and the total flavonoid content was 5.706 mg RU/g in the plant extract. The total saponins, alkaloids, and tannins contents were (0.044%), (2.88%) and (2.862 nm) respectively. α-amylase inhibition activity of Calligonum polygonoides (CP) extract was 70% with IC50 of 610 μg/mL and that of β-gluco-sidase inhibition activity was 65% with IC50 of 640 µg/mL.
CONCLUSION
The findings reported for the first time the antidiabetes-promoting effects of an extract of CP, thus validating their promising anti-diabetes potential.
目的
评估植物化学物质的存在，并测定其对α-淀粉酶和β-葡萄糖苷酶抑制的抗糖尿病活性。
方法
该研究按照标准程序进行。
结果
植物化学物质分析表明存在不同的植物化学物质。植物提取物中的总酚含量为 6.055 mg GAE/g，总黄酮含量为 5.706 mg RU/g。总皂苷、生物碱和单宁的含量分别为（0.044%）、（2.88%）和（2.862nm）。Calligonum polygonoides（CP）提取物对α-淀粉酶的抑制活性为 70%，IC50 为 610μg/mL，对β-葡萄糖苷酶的抑制活性为 65%，IC50 为 640μg/mL。
结论
首次报道了 CP 提取物具有促进糖尿病的作用，从而验证了其具有有希望的抗糖尿病潜力。
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