South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Trends Mol Med. 2022 Aug;28(8):662-680. doi: 10.1016/j.molmed.2022.04.012. Epub 2022 May 3.
COVID-19 caused by SARS-CoV-2 coronavirus has been associated with severe illness in pregnant women. Furthermore, COVID-19 during pregnancy is associated with adverse fetal outcomes including preterm labor. Pregnant women were largely excluded from initial clinical trials investigating the safety and efficacy of COVID-19 vaccines; however, they have since been included as part of the routine roll-out of these vaccines. This narrative review synthesizes the evidence on the safety, immunogenicity, and effectiveness predominantly of the mRNA COVID-19 vaccines which have been most widely used in pregnant women.
由严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）引起的 COVID-19 已与孕妇的重症相关。此外，妊娠期间的 COVID-19 与不良胎儿结局相关，包括早产。最初的临床试验主要排除了孕妇，这些试验旨在研究 COVID-19 疫苗的安全性和有效性；然而，此后她们被纳入这些疫苗常规推广的一部分。本综述性叙述主要综合了安全性、免疫原性和有效性方面的证据，这些证据主要来自于在孕妇中最广泛使用的信使 RNA（mRNA）COVID-19 疫苗。
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