Pulmonary infection coexisting with subcutaneous infection in a patient: A case report.

BACKGROUND

and () infections rarely occur in humans. Mutations in human caspase recruitment domain protein 9 (CARD9) are reported to be associated with fungal diseases. Pulmonary infection coexisting with subcutaneous infection in a patient with a CARD9 mutation has not been reported in the literature.

CASE SUMMARY

A 68-year-old male patient was hospitalized for hypertrophic erythema and deep ulcers on the left upper extremity. He was diagnosed with pneumonia caused by , as identified through bronchoalveolar lavage fluid analysis, and deep dermatophytosis caused by , as identified through morphological characteristics of the wound secretion culture. He underwent antifungal therapy (voriconazole) and recovered successfully. He carried two mutations in CARD9 (chr9:139266425 and chr9:139262240) and was therefore susceptible to fungal infections.

CONCLUSION

This case study is the first to report the coexistence of pulmonary infection and subcutaneous infection in a patient with CARD9 mutation. Our findings will be helpful in enriching the phenotypic spectrum of fungal infections underlying CARD9 deficiency.