Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.
Mol Biol Rep. 2022 Oct;49(10):9841-9853. doi: 10.1007/s11033-022-07503-0. Epub 2022 May 25.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases and closely associated with lipid disorder. Mitochondrion has been recognized to play a key role in lipid metabolism as the main site of energy metabolism in cells, and its dysfunction is involved in the progression of NAFLD. MicroRNAs (miRNAs), one of regulators in the pathogenesis of NAFLD, are discovered to modulate mitochondrial function by targeting mitochondrial proteins or mitochondrial-related factors, thereby improving or deteriorating NAFLD-associated pathologies. This review summarizes the differentially expressed miRNAs from clinical and experimental models of NAFLD with abilities in regulating mitochondrial function, expounds their underlying molecular mechanism and discusses their prospect and future research direction.
非酒精性脂肪性肝病（NAFLD）是最常见的代谢性疾病之一，与脂质代谢紊乱密切相关。线粒体作为细胞能量代谢的主要场所，其在脂质代谢中起着关键作用，其功能障碍与 NAFLD 的进展有关。微小 RNA（miRNA）是 NAFLD 发病机制中的调节因子之一，现已发现其通过靶向线粒体蛋白或与线粒体相关的因子来调节线粒体功能，从而改善或恶化与 NAFLD 相关的病理。本综述总结了具有调节线粒体功能能力的 NAFLD 临床和实验模型中差异表达的 miRNA，阐述了其潜在的分子机制，并讨论了其前景和未来的研究方向。
