Departments of Molecular Cellular and Developmental Biology, Departments of Molecular Biophysics and Biochemistry, and Department of Cell Biology, Yale University, New Haven, CT 06520-8103.
Mol Biol Cell. 2022 Jun 1;33(7):rt2. doi: 10.1091/mbc.E21-08-0401.
During the late 1960s four independent lines of research implicated actin in cellular motility. This Retrospective recounts how biochemistry, light and electron microscopy, and inhibitory natural products all contributed to this breakthrough.
20 世纪 60 年代末,有四条独立的研究线索将肌动蛋白与细胞运动联系起来。本文回顾了生物化学、光镜和电镜以及抑制性天然产物如何促成这一突破。