State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Adv Healthc Mater. 2022 Aug;11(15):e2200242. doi: 10.1002/adhm.202200242. Epub 2022 Jun 9.
The construction of organelle-targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle-targeting aggregation-induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle-targeting imaging-guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy.
细胞器靶向纳米材料的构建是提高肿瘤成像和治疗效果的有效方法。在这里，开发了一种新型的复合纳米材料，名为 PTTPB。PTTPB 由细胞器靶向聚集诱导发射光敏剂 TTPB 和聚多巴胺纳米材料组成。通过 TTPB 的功能修饰，PTTPB 可以识别细胞膜上的唾液酸，并呈现出线粒体靶向能力。通过细胞膜的识别过程，可以增加癌细胞对 PTTPB 的摄取。PTTPB 可以产生用于光动力治疗（PDT）的单线态氧，并在照射下呈现出良好的光热转换能力。具有细胞器靶向成像指导的 PTTPB 可以通过 PDT 和光热治疗的协同作用实现肿瘤消融。
