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增加基于组织的功能基因组学数据集多样性以了解人类疾病易感性的理由。

The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility.

机构信息

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

The Translational Genomics Research Institute, Phoenix, AZ, USA.

出版信息

Nat Commun. 2022 May 25;13(1):2907. doi: 10.1038/s41467-022-30650-8.

DOI:10.1038/s41467-022-30650-8
PMID:35614099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9133089/
Abstract

Tissue-based functional genomics resources including molecular quantitative trait loci datasets lack diversity in ancestry and tissue types and thus are inadequate for comprehensively investigating gene regulation. Global efforts to increase the tissue diversity will help achieve more equitable medical care.

摘要

基于组织的功能基因组学资源，包括分子数量性状位点数据集，在祖先和组织类型方面缺乏多样性，因此不足以全面研究基因调控。全球增加组织多样性的努力将有助于实现更公平的医疗保健。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b0/9133089/d49caaaf71c3/41467_2022_30650_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b0/9133089/d49caaaf71c3/41467_2022_30650_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b0/9133089/d49caaaf71c3/41467_2022_30650_Fig1_HTML.jpg

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