Programa de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Rio Grande - FURG, Rio Grande, Rio Grande do Sul, Brazil.
Programa de Pós-graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, Rio Grande do Sul, Brazil.
Phytother Res. 2022 Jul;36(7):2852-2877. doi: 10.1002/ptr.7497. Epub 2022 May 25.
Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. In the present study, we summarize and discuss the neuroprotective effects of polydatin in CNS disorders and related pathological conditions in preclinical animal studies. A systematic review was performed by searching online databases, returning a total of 110 records, where 27 articles were selected and discussed here. The included studies showed neuroprotective effects of polydatin in experimental models of neurological disorders, including cerebrovascular disorders, Parkinson's disease, traumatic brain injuries, diabetic neuropathy, glioblastoma, and neurotoxicity induced by chemical agents. Most studies were focused on stroke (22.2%) and conducted in male rodents. The intervention protocol with polydatin was mainly acute (66.7%), with postdamage induction treatment being the most commonly used regimen (55.2%). Overall, polydatin ameliorated behavioral dysfunctions and/or promoted neurological function by virtue of its antioxidant and antiinflammatory properties. In summary, this review offers important scientific evidence for the neuroprotective effects and distinct pharmacological mechanisms of polydatin that not only enhances the present understanding but is also useful for the development of future preclinical and clinical investigations.
白藜芦醇苷，又名白藜芦醇，是一种天然芪类化合物，存在于葡萄、花生和葡萄酒中。白藜芦醇具有多种药理学活性，包括神经保护作用，对中枢神经系统（CNS）疾病具有预防和/或治疗作用。在本研究中，我们总结和讨论了白藜芦醇苷在 CNS 疾病及相关病理状态的神经保护作用的临床前动物研究。通过在线数据库检索进行了系统评价，共返回 110 份记录，其中选择了 27 篇文章进行讨论。纳入的研究显示，白藜芦醇苷在包括脑血管疾病、帕金森病、创伤性脑损伤、糖尿病性神经病、胶质母细胞瘤和化学物质诱导的神经毒性在内的神经退行性疾病的实验模型中具有神经保护作用。大多数研究（22.2%）集中在中风，并且在雄性啮齿动物中进行。白藜芦醇苷的干预方案主要为急性（66.7%），最常用的方案是损伤后诱导治疗（55.2%）。总的来说，白藜芦醇苷通过其抗氧化和抗炎特性改善了行为功能障碍和/或促进了神经功能。综上所述，本综述为白藜芦醇苷的神经保护作用及其独特的药理机制提供了重要的科学证据，不仅增强了现有认识，而且对未来的临床前和临床研究也很有用。
