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Seizures may be an early sign of acute COVID-19, and the Omicron variant could present a more epileptogenic profile.癫痫发作可能是急性新冠病毒肺炎（COVID-19）的早期症状，而奥密克戎变异株可能具有更高的致癫痫倾向。
Acta Paediatr. 2022 Sep;111(9):1814-1815. doi: 10.1111/apa.16424. Epub 2022 Jun 9.
2
Seizure in children with severe acute respiratory syndrome coronavirus 2 Omicron variant infection.严重急性呼吸综合征冠状病毒2奥密克戎变异株感染儿童的癫痫发作
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Severe encephalopathy associated with SARS-CoV-2 Omicron BA.1 variant infection in a neonate.严重脑病与 SARS-CoV-2 奥密克戎 BA.1 变异株感染新生儿相关。
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Clinical features and predictive factors related to liver injury in SARS-CoV-2 Delta and Omicron variant-infected patients.新型冠状病毒德尔塔株和奥密克戎变异株感染患者肝损伤的临床特征及相关预测因素。
Eur J Gastroenterol Hepatol. 2022 Sep 1;34(9):933-939. doi: 10.1097/MEG.0000000000002381. Epub 2022 Apr 29.
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SARS-CoV-2 infection and seizures: the perfect storm.SARS-CoV-2 感染与癫痫发作：完美风暴。
J Integr Neurosci. 2022 Jun 20;21(4):115. doi: 10.31083/j.jin2104115.
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Provoked seizures and status epilepticus in a pediatric population with COVID-19 disease.COVID-19 疾病患儿中诱发性癫痫发作和癫痫持续状态。
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Possible Autoimmune Encephalitis with Claustrum Sign in case of Acute SARS-CoV-2 Infection.急性严重急性呼吸综合征冠状病毒2感染时可能伴有屏状核征的自身免疫性脑炎
Can J Neurol Sci. 2021 May;48(3):430-432. doi: 10.1017/cjn.2020.209. Epub 2020 Sep 17.
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Clinical characteristics of COVID-19 in hospitalized children during the Omicron variant predominant period.奥密克戎变异株流行期间住院儿童 COVID-19 的临床特征。
J Infect Chemother. 2022 Nov;28(11):1531-1535. doi: 10.1016/j.jiac.2022.08.004. Epub 2022 Aug 10.
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Clinical Characteristics and Outcomes Among Adults Hospitalized with Laboratory-Confirmed SARS-CoV-2 Infection During Periods of B.1.617.2 (Delta) and B.1.1.529 (Omicron) Variant Predominance - One Hospital, California, July 15-September 23, 2021, and December 21, 2021-January 27, 2022.2021 年 7 月 15 日至 9 月 23 日和 2021 年 12 月 21 日至 2022 年 1 月 27 日期间，加利福尼亚州一家医院因实验室确诊的 SARS-CoV-2 感染住院的成年人的临床特征和结局，期间 B.1.617.2（德尔塔）和 B.1.1.529（奥密克戎）变异株占主导地位。
MMWR Morb Mortal Wkly Rep. 2022 Feb 11;71(6):217-223. doi: 10.15585/mmwr.mm7106e2.

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Neurological Complications of COVID-19 Infection: A Comprehensive Review.新型冠状病毒肺炎感染的神经系统并发症：全面综述
Cureus. 2024 Jul 23;16(7):e65192. doi: 10.7759/cureus.65192. eCollection 2024 Jul.
2
Brain magnetic resonance imaging findings in children with neurological complications of coronavirus disease 2019 (Omicron variant): a multicenter retrospective observational study.2019冠状病毒病（奥密克戎变异株）神经并发症患儿的脑磁共振成像结果：一项多中心回顾性观察研究
Pediatr Radiol. 2024 May;54(6):1012-1021. doi: 10.1007/s00247-024-05908-6. Epub 2024 Mar 28.
3
Long-term effects of SARS-CoV-2 infection in hospitalized children: findings from an Italian single-center study.长期随访：意大利单中心研究揭示儿童严重急性呼吸综合征冠状病毒 2 感染的临床转归
Ital J Pediatr. 2024 Feb 14;50(1):27. doi: 10.1186/s13052-024-01596-y.
4
Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study.在 COVID-19 大流行期间，因 SARS-CoV-2 住院的儿科患者的发作情况，并与因其他呼吸道病毒住院的儿科患者的发作严重程度进行比较：一项基于人群的队列研究。
Arch Dis Child. 2024 Jan 22;109(2):152-157. doi: 10.1136/archdischild-2023-325974.
5
[Clinical features of children with coronavirus disease 2019 in different age groups during the epidemic of Omicron variant].[奥密克戎变异株流行期间不同年龄组儿童新型冠状病毒肺炎的临床特征]
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Jun 15;25(6):600-605. doi: 10.7499/j.issn.1008-8830.2302014.
6
Afebrile benign convulsions with or without a reversible splenial lesion in two pediatric patients with COVID-19.两例 COVID-19 患儿出现无热良性惊厥伴或不伴可逆性胼胝体病变。
BMC Pediatr. 2023 Apr 26;23(1):198. doi: 10.1186/s12887-023-04025-x.
7
Seizures in Children with SARS-CoV-2 Infection: Epidemiological, Clinical and Neurophysiological Characterization.感染新型冠状病毒2的儿童癫痫发作：流行病学、临床及神经生理学特征
Children (Basel). 2022 Dec 8;9(12):1923. doi: 10.3390/children9121923.

本文引用的文献

1
Convulsions in children with COVID-19 during the Omicron wave.奥密克戎变异株流行期间儿童 COVID-19 相关惊厥
Acta Paediatr. 2022 May;111(5):1023-1026. doi: 10.1111/apa.16276. Epub 2022 Feb 10.
2
Seizures as the main presenting manifestation of acute SARS-CoV-2 infection in children.以癫痫发作为主要表现的儿童急性 SARS-CoV-2 感染。
Seizure. 2021 Nov;92:89-93. doi: 10.1016/j.seizure.2021.08.017. Epub 2021 Aug 28.
3
Acute encephalitis in pediatric multisystem inflammatory syndrome associated with COVID-19.与新型冠状病毒肺炎相关的儿童多系统炎症综合征中的急性脑炎
Eur J Paediatr Neurol. 2021 Sep;34:84-90. doi: 10.1016/j.ejpn.2021.07.010. Epub 2021 Aug 5.
4
A follow-up study of patients with COVID-19 presenting with seizures.伴有癫痫发作的 COVID-19 患者的随访研究。
Epilepsy Behav. 2021 Sep;122:108207. doi: 10.1016/j.yebeh.2021.108207. Epub 2021 Jul 2.
5
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.美国因新冠病毒病或多系统炎症综合征住院的儿童和青少年的神经系统受累情况
JAMA Neurol. 2021 May 1;78(5):536-547. doi: 10.1001/jamaneurol.2021.0504.

Seizures may be an early sign of acute COVID-19, and the Omicron variant could present a more epileptogenic profile.

作者信息

Bova Stefania Maria, Serafini Ludovica, Serati Ilaria, Fiori Laura, Veggiotti Pierangelo

机构信息

Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy.

University of Milan, Milan, Italy.

出版信息

Acta Paediatr. 2022 Sep;111(9):1814-1815. doi: 10.1111/apa.16424. Epub 2022 Jun 9.

DOI:10.1111/apa.16424
PMID:35615863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9348245/
Abstract
摘要