Lai H, Bowden D M, Horita A
Neurobiol Aging. 1987 Jan-Feb;8(1):45-9. doi: 10.1016/0197-4580(87)90056-x.
Specific binding of the dopamine receptor ligand 3H-spiroperidol to cell membranes prepared from the caudate nuclei and putamens of 29 rhesus monkeys (M. mulatta), ranging in age from 2 to 22 years, was investigated. Receptor concentration (Bmax) decreased in the caudate nucleus and putamen with age at mean rates of 2.1 and 1.7% per year, respectively, whereas binding affinity (Kd) did not change significantly with age. The rate of decline in Bmax appeared to be more rapid before adulthood and in old age than during young adulthood and middle age. These data are compared with the results from similar studies of other animal species including human, rabbit, rat, and mouse. The rate of decline in striatal dopamine receptors is closely related to the rate of aging and maximal life span of the species. It may reflect both maturational and senescent processes modifying the behavior of animals as they age.
研究了多巴胺受体配体3H-螺哌啶醇与29只年龄在2至22岁之间的恒河猴（猕猴）尾状核和壳核制备的细胞膜的特异性结合。受体浓度（Bmax）在尾状核和壳核中随年龄增长而下降，平均每年分别下降2.1%和1.7%，而结合亲和力（Kd）随年龄没有显著变化。Bmax的下降速率在成年前和老年似乎比年轻成年期和中年期更快。将这些数据与其他动物物种（包括人类、兔子、大鼠和小鼠）的类似研究结果进行了比较。纹状体多巴胺受体的下降速率与物种的衰老速率和最大寿命密切相关。它可能反映了随着动物年龄增长而改变其行为的成熟和衰老过程。
