Morgan D G, Marcusson J O, Nyberg P, Wester P, Winblad B, Gordon M N, Finch C E
Neurobiol Aging. 1987 May-Jun;8(3):195-201. doi: 10.1016/0197-4580(87)90002-9.
The density of D-1 and D-2 dopamine receptors in human caudate nucleus and putamen, obtained postmortem, were studied throughout the adult lifespan using [3H]fluphenazine as the dopamine receptor ligand. The D-1 subtype increased progressively with age in both regions, while the D-2 subtype declined in caudate nucleus. The ratio of D-1/D-2 Bmax in both regions increased from approximately 1 at age 20 to 2 by age 75. The dopamine content in putamen declined with age and was inversely correlated with D-1 receptor density. We suggest that D-1 receptor density is up-regulated by loss of dopamine during aging. The D-2 receptor density in caudate nucleus was positively correlated with choline acetyltransferase activity, suggesting that loss of intrastriatal neurons with age may contribute to the decrease in D-2 sites. These divergent changes in dopamine receptor subtypes with age result in an altered complement of dopamine receptors in older humans and may provide a basis for selective pharmacotherapy in disorders of the basal ganglia.
利用[3H]氟奋乃静作为多巴胺受体配体，对成年期各年龄段死后获取的人脑尾状核和壳核中D-1和D-2多巴胺受体的密度进行了研究。在这两个区域中，D-1亚型受体密度随年龄增长而逐渐增加，而尾状核中的D-2亚型受体密度则下降。两个区域中D-1/D-2最大结合容量（Bmax）的比值从20岁时的约1增加到75岁时的2。壳核中的多巴胺含量随年龄下降，且与D-1受体密度呈负相关。我们认为，衰老过程中多巴胺的丧失会使D-1受体密度上调。尾状核中的D-2受体密度与胆碱乙酰转移酶活性呈正相关，这表明随着年龄增长纹状体内神经元的丧失可能导致D-2受体位点减少。多巴胺受体亚型随年龄的这些不同变化导致老年人多巴胺受体组成改变，可能为基底神经节疾病的选择性药物治疗提供依据。
