School of Immunology and Microbial Sciences, King's College London, London, UK.
School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.
Trends Immunol. 2022 Jul;43(7):564-579. doi: 10.1016/j.it.2022.04.009. Epub 2022 May 23.
Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic and disease settings, such as inflammatory bowel disease (IBD), particularly in the context of maintaining the integrity of mucosal surfaces. Early reports highlighted group 1 and 3 ILC regulatory transcription factors (TFs), T-box expressed in T cells (T-bet; Tbx21) and RAR-related orphan nuclear receptor γt (RORγt; Rorc), as key regulators of ILC biology. Since then, other canonical TFs have been shown to have a role in the development and function of ILC subsets. In this review, we focus on recent insights into the balance between mature ILC1 and ILC3 based on these TFs and how they interact with other key cell-intrinsic molecular pathways. We outline how this TF interplay might be explored to identify novel candidate therapeutic avenues for human diseases.
哺乳动物固有淋巴细胞 (ILC) 在稳态和疾病环境下具有功能相关性，例如炎症性肠病 (IBD)，特别是在维持黏膜表面完整性方面。早期报告强调了 I 型和 III 型 ILC 调节转录因子 (TF)，T 细胞表达的 T 盒 (T-bet; Tbx21) 和维甲酸相关孤儿核受体 γt (RORγt; Rorc)，作为 ILC 生物学的关键调节因子。此后，其他经典 TF 已被证明在 ILC 亚群的发育和功能中发挥作用。在这篇综述中，我们重点介绍了基于这些 TF 的成熟 ILC1 和 ILC3 之间平衡的最新见解，以及它们如何与其他关键细胞内在分子途径相互作用。我们概述了如何探索这种 TF 相互作用来确定人类疾病的新候选治疗途径。
