血小板衍生生长因子在体外对大鼠脑胶质细胞是一种促分裂原，但对神经元细胞则不是。
Platelet-derived growth factor is a mitogen for glial but not for neuronal rat brain cells in vitro.
作者信息
Besnard F, Perraud F, Sensenbrenner M, Labourdette G
出版信息
Neurosci Lett. 1987 Jan 27;73(3):287-92. doi: 10.1016/0304-3940(87)90260-6.
PMID:3561869
Abstract
The effects of platelet-derived growth factor (PDGF) on the proliferation of isolated rat neural cells grown in serum-free chemically defined media have been investigated. It was found that PDGF drastically stimulates the proliferation of astroblasts and oligodendroblasts, but has no effect on the proliferation of neuroblasts in primary culture. A role of PDGF in the reactive gliosis, occurring after brain injury, can be suggested.
摘要
研究了血小板衍生生长因子（PDGF）对在无血清化学限定培养基中培养的离体大鼠神经细胞增殖的影响。结果发现，PDGF能显著刺激星形胶质细胞和成少突胶质细胞的增殖，但对原代培养中的神经母细胞增殖没有影响。可以推测PDGF在脑损伤后发生的反应性胶质增生中起作用。
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