Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao, China.
Department of Neurology and Institute of Neurology, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Alzheimers Res Ther. 2022 May 26;14(1):74. doi: 10.1186/s13195-022-01019-2.
This study sought to explore the association between Life's Simple 7 (LS7) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathological biomarkers in the cognitively normal northern Chinese population.
From the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study, 1106 cognitively normal participants were enrolled. The mean age was 62.34 years, and 39.6% were female. LS7 scores were summed with each metric assigned 0, 1, or 2 scores. The multiple linear regression models were used to investigate the association between LS7 scores and CSF AD biomarkers.
We found that LS7 scores were significantly associated with CSF AD pathologies, including Aβ42/40 (β = 0.034, P = .041), p-tau181 (β = - 0.043, P = .006), and t-tau (β = - 0.044, P = .003). In subscales, the biological metrics (blood pressure, cholesterol, glucose) were significantly related to CSF tau-related biomarkers. These associations were observed in the APOE ε4 allele non-carriers, yet not in carriers. The relationship of behavior metrics was found in the middle age and males.
Improving LS7 scores might do a favor to alleviate the pathology of AD in the preclinical stage, especially among the APOE ε4 allele non-carriers.
本研究旨在探讨生活简单 7 项指标（LS7）与中国北方认知正常人群脑脊液（CSF）阿尔茨海默病（AD）病理生物标志物之间的关系。
本研究纳入了中国阿尔茨海默病生物标志物和生活方式研究（CABLE）中的 1106 名认知正常的参与者。参与者的平均年龄为 62.34 岁，其中 39.6%为女性。LS7 评分是通过将每项指标分配 0、1 或 2 分进行累加得到的。我们采用多元线性回归模型来研究 LS7 评分与 CSF AD 生物标志物之间的关系。
我们发现 LS7 评分与 CSF AD 病理标志物显著相关，包括 Aβ42/40（β=0.034，P=0.041）、p-tau181（β= -0.043，P=0.006）和 t-tau（β= -0.044，P=0.003）。在亚量表中，生物学指标（血压、胆固醇、血糖）与 CSF tau 相关生物标志物显著相关。这些关联在 APOE ε4 等位基因非携带者中观察到，但在携带者中未观察到。行为学指标的相关性仅在中年和男性中观察到。
提高 LS7 评分可能有助于减轻临床前阶段 AD 的病理变化，特别是在 APOE ε4 等位基因非携带者中。
