Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA.
Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific St, Box 356560, Seattle, WA, 98195, USA.
Alzheimers Res Ther. 2017 Jul 3;9(1):48. doi: 10.1186/s13195-017-0271-9.
This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) and cerebrovascular injury across the life span of cognitively normal adults.
CSF amyloid beta (Aβ), phospho-tau-181 (p-tau), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100.
CSF total tau and p-tau increased with age over the adult life span (p < 0.01) with no gender differences in those increases. CSF Aβ concentration varied according to age, gender, and APOE genotype (interaction of age × gender × ε4, p = 0.047). CSF VCAM1, but not E-selectin, increased with age (p < 0.01), but both were elevated in men compared to women (p < 0.01).
Female APOE-ε4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age.
本研究旨在评估性别和 APOE 基因型与认知正常成年人整个生命周期内阿尔茨海默病（AD）和脑血管损伤的脑脊液（CSF）生物标志物浓度的关系。
对年龄在 21 至 100 岁之间的 331 名参与者进行 CSF 淀粉样蛋白β（Aβ）、磷酸化 tau-181（p-tau）和总 tau 的测量。对年龄在 50 至 100 岁之间的 249 名参与者进行 CSF E-选择素和血管细胞黏附蛋白 1（VCAM1）的测量。
CSF 总 tau 和 p-tau 在成年后随着年龄的增长而增加（p<0.01），但这些增加与性别无关。CSF Aβ 浓度随年龄、性别和 APOE 基因型而变化（年龄×性别×ε4 的相互作用，p=0.047）。CSF VCAM1 随着年龄的增长而增加（p<0.01），但与女性相比，男性的 VCAM1 和 E-选择素均升高（p<0.01）。
50 岁以后，女性 APOE-ε4 携带者出现 AD 的风险似乎更高。相比之下，男性可能在中年和早期老年时经历更高的脑血管损伤率。
