Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
J Cereb Blood Flow Metab. 2022 Dec;42(12):2351-2353. doi: 10.1177/0271678X221104868. Epub 2022 May 26.
Accumulating evidence suggests asymmetrical responses of cerebral blood flow during large transient changes in mean arterial pressure. Specifically, the augmentation in cerebral blood flow is attenuated when mean arterial pressure acutely increases, compared with declines in cerebral blood flow when mean arterial pressure acutely decreases. However, common analytical tools to quantify dynamic cerebral autoregulation assume autoregulatory responses to be symmetric, which does not seem to be the case. Herein, we provide the rationale supporting the notion we need to consider the directional sensitivity of large and transient mean arterial pressure changes when characterizing dynamic cerebral autoregulation.
越来越多的证据表明，在平均动脉压的大幅瞬时变化期间，脑血流呈非对称反应。具体而言，与平均动脉压急性下降时脑血流下降相比，当平均动脉压急性上升时，脑血流的增加被减弱。然而，用于量化动态脑自动调节的常见分析工具假设自动调节反应是对称的，但事实似乎并非如此。在此，我们提供了支持这一观点的基本原理，即当描述动态脑自动调节时，我们需要考虑大的和瞬时的平均动脉压变化的方向敏感性。
