在经过训练的潜水员进行最大程度屏气期间，动态脑自动调节功能会急性受损。
Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
作者信息
Cross Troy J, Kavanagh Justin J, Breskovic Toni, Johnson Bruce D, Dujic Zeljko
机构信息
Griffith Health Institute and Heart Foundation Research Centre, Griffith University, Gold Coast Campus, Queensland, Australia ; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America.
Griffith Health Institute and Heart Foundation Research Centre, Griffith University, Gold Coast Campus, Queensland, Australia.
出版信息
PLoS One. 2014 Feb 3;9(2):e87598. doi: 10.1371/journal.pone.0087598. eCollection 2014.
AIMS
To examine whether dynamic cerebral autoregulation is acutely impaired during maximal voluntary apnoea in trained divers.
METHODS
Mean arterial pressure (MAP), cerebral blood flow-velocity (CBFV) and end-tidal partial pressures of O2 and CO2 (PETO2 and PETCO2) were measured in eleven trained, male apnoea divers (28 ± 2 yr; 182 ± 2 cm, 76 ± 7 kg) during maximal "dry" breath holding. Dynamic cerebral autoregulation was assessed by determining the strength of phase synchronisation between MAP and CBFV during maximal apnoea.
RESULTS
The strength of phase synchronisation between MAP and CBFV increased from rest until the end of maximal voluntary apnoea (P<0.05), suggesting that dynamic cerebral autoregulation had weakened by the apnoea breakpoint. The magnitude of impairment in dynamic cerebral autoregulation was strongly, and positively related to the rise in PETCO2 observed during maximal breath holding (R (2) = 0.67, P<0.05). Interestingly, the impairment in dynamic cerebral autoregulation was not related to the fall in PETO2 induced by apnoea (R (2) = 0.01, P = 0.75).
CONCLUSIONS
This study is the first to report that dynamic cerebral autoregulation is acutely impaired in trained divers performing maximal voluntary apnoea. Furthermore, our data suggest that the impaired autoregulatory response is related to the change in PETCO2, but not PETO2, during maximal apnoea in trained divers.
目的
研究训练有素的潜水员在最大自主屏气期间动态脑自动调节是否会急性受损。
方法
在11名训练有素的男性屏气潜水员（28±2岁；身高182±2厘米，体重76±7千克）进行最大程度的“干式”屏气时，测量其平均动脉压（MAP）、脑血流速度（CBFV）以及呼气末氧分压和二氧化碳分压（PETO2和PETCO2）。通过测定最大屏气期间MAP和CBFV之间的相位同步强度来评估动态脑自动调节。
结果
从静息状态到最大自主屏气结束，MAP和CBFV之间的相位同步强度增加（P<0.05），这表明在屏气断点时动态脑自动调节已经减弱。动态脑自动调节的受损程度与最大屏气期间观察到的PETCO2升高呈强烈正相关（R (2) = 0.67，P<0.05）。有趣的是，动态脑自动调节的受损与屏气引起的PETO2下降无关（R (2) = 0.01，P = 0.75）。
结论
本研究首次报道，训练有素的潜水员在进行最大自主屏气时动态脑自动调节会急性受损。此外，我们的数据表明，在训练有素的潜水员最大屏气期间，自动调节反应受损与PETCO2的变化有关，而与PETO2无关。
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