Scholkmann Felix, Tachtsidis Ilias, Wolf Martin, Wolf Ursula
University of Bern, Institute of Complementary and Integrative Medicine, Bern, Switzerland.
University Hospital Zurich, University of Zurich, Biomedical Optics Research Laboratory, Neonatology Research, Department of Neonatology, Zurich, Switzerland.
Neurophotonics. 2022 Jul;9(3):030801. doi: 10.1117/1.NPh.9.3.030801. Epub 2022 Jul 11.
In this Outlook paper, we explain why an accurate physiological interpretation of functional near-infrared spectroscopy (fNIRS) neuroimaging signals is facilitated when systemic physiological activity (e.g., cardiorespiratory and autonomic activity) is measured simultaneously by employing systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). The rationale for SPA-fNIRS is twofold: (i) SPA-fNIRS enables a more complete interpretation and understanding of the fNIRS signals measured at the head since they contain components originating from neurovascular coupling and from systemic physiological sources. The systemic physiology signals measured with SPA-fNIRS can be used for regressing out physiological confounding components in fNIRS signals. Misinterpretations can thus be minimized. (ii) SPA-fNIRS enables to study the embodied brain by linking the brain with the physiological state of the entire body, allowing novel insights into their complex interplay. We envisage the SPA-fNIRS approach will become increasingly important in the future.
在这篇展望文章中，我们解释了为何当通过采用全身生理学增强功能近红外光谱技术（SPA-fNIRS）同时测量全身生理活动（如心肺和自主神经活动）时，有助于对功能近红外光谱（fNIRS）神经成像信号进行准确的生理学解释。SPA-fNIRS的基本原理有两个方面：（i）SPA-fNIRS能够对在头部测量的fNIRS信号进行更完整的解释和理解，因为这些信号包含源自神经血管耦合和全身生理源的成分。用SPA-fNIRS测量的全身生理信号可用于去除fNIRS信号中的生理混杂成分。因此，可以将错误解释降至最低。（ii）SPA-fNIRS能够通过将大脑与整个身体的生理状态联系起来研究具身化大脑，从而对它们之间复杂的相互作用有新的认识。我们设想SPA-fNIRS方法在未来将变得越来越重要。
