Schneiderman Deborah K, Ting Jeffrey M, Purchel Anatolii A, Miranda Ron, Tirrell Matthew V, Reineke Theresa M, Rowan Stuart J
Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Argonne National Laboratory, Lemont, Illinois 60439, United States.
ACS Macro Lett. 2018 Apr 17;7(4):406-411. doi: 10.1021/acsmacrolett.8b00069. Epub 2018 Mar 15.
We investigate the use of in situ enzyme degassing to facilitate the open-to-air reversible addition-fragmentation chain transfer (RAFT) polymerization of hydroxyethyl acrylate (HEA) in a wide range of complex aqueous solvents, including, beer, wine, liquor, and fermentation broth. This enzyme-assisted polymerization procedure is impressively robust, and poly(HEA) was attained with good control over molecular weight and a narrow dispersity in nearly all of the solvents tested. Kinetics experiments on HEA polymerization in whisky and spectroscopic analysis of the purified polymers suggest high end-group fidelity, as does the successful chain extension of a poly(HEA) macro chain transfer agent with narrow dispersity. These results suggest enzyme-assisted RAFT may be a powerful and underutilized tool for high-throughput screening and materials discovery and may simplify the synthesis of well-defined polymers in complex conditions.
我们研究了原位酶脱气在多种复杂水性溶剂（包括啤酒、葡萄酒、白酒和发酵液）中促进丙烯酸羟乙酯（HEA）的开放式可逆加成-断裂链转移（RAFT）聚合反应的应用。这种酶辅助聚合方法具有令人印象深刻的稳健性，在几乎所有测试的溶剂中都能很好地控制聚（HEA）的分子量并获得较窄的分散度。在威士忌中进行的HEA聚合动力学实验以及对纯化聚合物的光谱分析表明，端基保真度很高，具有窄分散度的聚（HEA）大分子链转移剂的成功链延伸也是如此。这些结果表明，酶辅助RAFT可能是一种强大但未充分利用的高通量筛选和材料发现工具，并且可能简化在复杂条件下合成结构明确的聚合物的过程。
