Sun Sibo, Wang Yu, Li Min, Wu Jianqing
Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Mol Biosci. 2022 May 10;9:861380. doi: 10.3389/fmolb.2022.861380. eCollection 2022.
The TRP (transient receptor potential) superfamily, as cation channels, is a critical chemosensor for potentially harmful irritants. Their activation is closely related not only to tumor progression and prognosis but also to tumor therapy response. Nevertheless, the TRP-related immune gene (TRIG) expression of the tumor microenvironment (TME) and the associations with prognosis remain unclear. First, we represented the transcriptional and genetic variations in TRIGs in 535 lung adenocarcinoma (LUAD) samples as well as their expression patterns. LUAD samples were divided into two distinct subtypes based on the TRIG variations. Significant differences had been found in prognosis, clinical features, and TME cell-infiltration features between the two subtypes of patients. Second, we framed a TRIG score for predicting overall survival (OS) and validated the predictive capability of the TRIG score in LUAD patients. Accordingly, to enhance the clinical applicability of TRIG score, we developed a considerable nomogram. A low TRIG score, characterized by increased immunity activation, indicated favorable advantages of OS compared with a high TRIG score. Furthermore, the TRIG score was found to have a significant connection with the TME cell-infiltration and immune checkpoint expressions. Our analysis of TRIGs in LUAD showed their potential roles in prognosis, clinical features, and tumor-immune microenvironments. These results may advance our knowledge of TRP genes in LUAD and show a new light on prognosis estimation and the improvement of immunotherapy strategies.
瞬时受体电位（TRP）超家族作为阳离子通道，是潜在有害刺激物的关键化学传感器。它们的激活不仅与肿瘤进展和预后密切相关，还与肿瘤治疗反应有关。然而，肿瘤微环境（TME）中与TRP相关的免疫基因（TRIG）表达及其与预后的关联仍不清楚。首先，我们展示了535例肺腺癌（LUAD）样本中TRIG的转录和基因变异及其表达模式。基于TRIG变异，LUAD样本被分为两种不同的亚型。在这两种亚型患者的预后、临床特征和TME细胞浸润特征方面发现了显著差异。其次，我们构建了一个用于预测总生存期（OS）的TRIG评分，并验证了该评分在LUAD患者中的预测能力。因此，为了提高TRIG评分的临床适用性，我们开发了一个实用的列线图。低TRIG评分以免疫激活增加为特征，与高TRIG评分相比，显示出OS的有利优势。此外，发现TRIG评分与TME细胞浸润和免疫检查点表达有显著关联。我们对LUAD中TRIG的分析显示了它们在预后、临床特征和肿瘤免疫微环境中的潜在作用。这些结果可能会增进我们对LUAD中TRP基因的了解，并为预后评估和免疫治疗策略的改进提供新的思路。
