木尘对肺功能及血液免疫球蛋白E、红细胞沉降率和C反应蛋白的影响：孟加拉国坦盖尔锯木厂工人的横断面研究

The impact of wood dust on pulmonary function and blood immunoglobulin E, erythrocyte sedimentation rate, and C- reactive protein: A cross-sectional study among sawmill workers in Tangail, Bangladesh.

作者信息

Mogal Md Roman, Islam Md Didarul, Hasan Md Ikbal, Junayed Asadullah, Sompa Sagarika Adhikary, Mahmod Md Rashel, Akter Aklima, Abedin Md Zainul, Sikder Md Asaduzzaman

机构信息

Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University Tangail Bangladesh.

Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Bangladesh.

出版信息

Health Sci Rep. 2022 May 22;5(3):e646. doi: 10.1002/hsr2.646. eCollection 2022 May.

DOI:10.1002/hsr2.646

PMID:35620547

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9124949/

Abstract

BACKGROUND AND AIMS

Occupational exposure to wood dust leads to lung function abnormalities that are prominent causes of morbidity and disability of sawmill workers. The adverse respiratory effects of wood dust in sawmills have not been studied thoroughly in Bangladesh. This study aimed to investigate the effect of wood dust on the respiratory health of sawmill workers compared to controls as well as to determine the association of wood dust-exposing effects with inflammatory blood biomarkers, such as immunoglobulin E (IgE), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).

METHODS

This cross-sectional study included 100 sawmill workers from 25 distinct sawmills in various areas of Tangail, Bangladesh as well as 100 healthy volunteers who were adopted as a control group. Questionaries' survey and pulmonary function tests were performed face to face. Furthermore, after performing lung function tests, blood was drawn for further IgE, ESR, and CRP analyses.

RESULTS

Respiratory symptoms including breathlessness (32%), coughing (39%), sneezing (43%), chest tightness (30%), and itching (40%) were significantly higher in sawmill workers compared with control. Besides, sawmill workers' exposure to wood dust revealed a significantly lower level of spirometry parameters (forced vital capacity [FVC], FVC (%), forced expiratory volume in 1 s [FEV1], FEV1 (%), peak expiratory flow [PEF], PEF (%), FEV1/FVC (%), FEF25, FEF75, and FEF2575) compared with control and these spirometry parameters decreased with the increasing length of service. Moreover, a significantly higher level of IgE was observed in sawmill workers (290.90 ± 39.49) than in the control (120.95 ± 23.00). The high level of IgE suggests that the lower pulmonary function may be linked to allergic responses to wood dust among sawmill workers.

CONCLUSION

This study suggested that exposure to wood dust can cause impairment of respiratory function along with high IgE levels.

摘要

背景与目的

职业性接触木尘会导致肺功能异常，这是锯木厂工人发病和致残的主要原因。在孟加拉国，尚未对锯木厂中木尘对呼吸系统的不良影响进行深入研究。本研究旨在调查与对照组相比，木尘对锯木厂工人呼吸健康的影响，并确定木尘暴露效应与炎症性血液生物标志物（如免疫球蛋白E（IgE）、红细胞沉降率（ESR）和C反应蛋白（CRP））之间的关联。

方法

这项横断面研究纳入了来自孟加拉国坦盖尔不同地区25家不同锯木厂的100名锯木厂工人，以及100名健康志愿者作为对照组。面对面进行问卷调查和肺功能测试。此外，在进行肺功能测试后，采集血液以进一步分析IgE、ESR和CRP。

结果

与对照组相比，锯木厂工人的呼吸症状，如气喘（32%）、咳嗽（39%）、打喷嚏（43%）、胸闷（30%）和瘙痒（40%）明显更高。此外，锯木厂工人接触木尘后，其肺量计参数（用力肺活量[FVC]、FVC（%）、第1秒用力呼气量[FEV1]、FEV1（%）、呼气峰值流速[PEF]、PEF（%）、FEV1/FVC（%）、FEF25、FEF75和FEF2575）水平明显低于对照组，且这些肺量计参数随服务年限的增加而降低。此外，锯木厂工人的IgE水平（290.90±39.49）明显高于对照组（120.95±23.00）。高水平的IgE表明，较低的肺功能可能与锯木厂工人对木尘的过敏反应有关。