Jacobsen Gitte, Schaumburg Inger, Sigsgaard Torben, Schlunssen Vivi
Department of Environmental and Occupational Medicine, School of Public Health, Aarhus University, Aarhus C, Denmark.
Ann Agric Environ Med. 2010;17(1):15-28.
This paper reviews associations in literature between exposure to wood dust from fresh wood and non-malignant respiratory diseases. Criteria for inclusion are epidemiological studies in English language journals with an internal or external control group describing relationships between wood dust exposure and respiratory diseases or symptoms. The papers took into account smoking, and when dealing with lung function took age into consideration. A total of 25 papers concerning exposure to fresh wood and mixed wood formed the basis of this review. The results support an association between fresh wood dust exposure and asthma, asthma symptoms, coughing, bronchitis, and acute and chronic impairment of lung function. In addition, an association between fresh wood dust exposure and rhino-conjunctivitis was seen across studies. Apart from plicatic acid in western red cedar wood, no causal agent was consistently disclosed. Type 1 allergy is not suspected of being a major cause of wood dust induced asthma. Concurrent exposure to microorganisms and terpenes probably add to the inherent risk of wood dust exposure in the fresh wood industry.
本文综述了文献中新鲜木材产生的木屑暴露与非恶性呼吸道疾病之间的关联。纳入标准为英文期刊上的流行病学研究，研究需设有内部或外部对照组，描述木屑暴露与呼吸道疾病或症状之间的关系。这些论文考虑了吸烟因素，在研究肺功能时还考虑了年龄因素。共有25篇关于新鲜木材和混合木材暴露的论文构成了本综述的基础。结果支持新鲜木屑暴露与哮喘、哮喘症状、咳嗽、支气管炎以及肺功能的急性和慢性损害之间存在关联。此外，各项研究均发现新鲜木屑暴露与鼻结膜炎之间存在关联。除了西部红雪松木材中的plicatic酸外，未始终发现有因果关系的致病因素。1型过敏不被怀疑是木屑诱发哮喘的主要原因。同时暴露于微生物和萜类物质可能会增加新鲜木材行业中木屑暴露的固有风险。
