Wang Zhuangyi, Zhang Zhengzhong
Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jun 5;18:1423-1429. doi: 10.2147/CCID.S524611. eCollection 2025.
Rosacea is a chronic inflammatory skin disease primarily affecting the central region of the face. Typical manifestations include erythema, papules, or pustules on the cheeks, glabella, chin, and nose, with some patients experiencing ocular involvement. The pathogenesis of this disease is influenced by both polygenic inheritance and environmental factors, with abnormalities in innate immunity and neurovascular regulation playing a leading role. Recent genetic studies have identified several key genes, including Human Leukocyte Antigen (HLA), Toll-Like Receptor 2 (TLR2), Interleukin-17 (IL-17), Cathelicidin Antimicrobial Peptide (CAMP), and others, that are closely associated with rosacea onset and progression. This review summarized recent advances in rosacea-related genetic researches, aiming to reveal the genetic basis of the disease and provide support for early intervention and precision management of high-risk populations.
酒渣鼻是一种主要影响面部中央区域的慢性炎症性皮肤病。典型表现包括脸颊、眉间、下巴和鼻子上出现红斑、丘疹或脓疱，部分患者还会出现眼部受累。该病的发病机制受多基因遗传和环境因素的影响，先天免疫和神经血管调节异常起主导作用。最近的基因研究已经确定了几个关键基因，包括人类白细胞抗原（HLA）、Toll样受体2（TLR2）、白细胞介素-17（IL-17）、杀菌肽抗菌肽（CAMP）等，这些基因与酒渣鼻的发病和进展密切相关。本综述总结了酒渣鼻相关基因研究的最新进展，旨在揭示该病的遗传基础，并为高危人群的早期干预和精准管理提供支持。
