Leaders Aesthetic Laser and Cosmetic Surgery Center, Seoul 06014, Korea.
Department of Dermatology, Sungkyunkwan University School of Medicine, Seoul 06355, Korea.
Toxins (Basel). 2022 May 4;14(5):329. doi: 10.3390/toxins14050329.
The efficacy and safety of botulinum toxin injection have made it a popular aesthetic procedure worldwide. A cross-sectional survey was performed in order to determine the pattern of type A botulinum toxin injections in cosmetic practice, for which an 18-item questionnaire was distributed to dermatologists. A total of 469 Korean board-certified dermatologists participated in the survey, with the following results: the main candidates for type A botulinum toxin injection were individuals in their 40-50 years (46.1%), followed by those in their 20-30 years (33.4%), and people over 60 years of age (20.5%). Overall, the upper face (the glabella, forehead, and crow's line, in decreasing order) was the most favored area of injection (51%). In contrast, body contouring (i.e., shoulder, calf) and treatment for benign masseter hypertrophy were significantly more popular in the 20-30 years age group than their older counterparts. For wrinkle effacement, the most preferred dilution was 100 units/2.5 mL with isotonic sodium chloride injection (51.2%), and the most often used interval was six months (43.6%). About half (46.3%) of the dermatologists reported the experience of clinical cases which were suspicious of botulinum toxin resistance. Despite this, regarding the choice of the product, type A botulinum toxin products with greater cost-effectiveness were favored over products with a lower risk of antibody formation. Other than its cosmetic usage, botulinum toxin is applied for a variety of skin conditions. Further studies are suggested in order to identify the practice pattern of type A botulinum toxin for therapeutic uses in dermatology, such as hyperhidrosis and rosacea.
肉毒毒素注射的疗效和安全性使其成为全球流行的美容程序。为了确定美容实践中 A 型肉毒毒素注射的模式，进行了一项横断面调查，为此向皮肤科医生分发了一份包含 18 个问题的问卷。共有 469 名韩国委员会认证的皮肤科医生参与了这项调查，结果如下：A 型肉毒毒素注射的主要候选人群是 40-50 岁的个体（46.1%），其次是 20-30 岁的个体（33.4%）和 60 岁以上的个体（20.5%）。总体而言，上面部（眉间、额头和鱼尾纹，依次递减）是最受欢迎的注射部位（51%）。相比之下，20-30 岁年龄组的身体轮廓（即肩部、小腿）和良性咬肌肥大的治疗明显比其年长组更受欢迎。对于皱纹消除，最受欢迎的稀释度是 100 单位/2.5 毫升与等渗氯化钠注射（51.2%），最常用的间隔是六个月（43.6%）。大约一半（46.3%）的皮肤科医生报告了怀疑对肉毒毒素有抵抗力的临床病例的经验。尽管如此，在产品选择方面，具有更高成本效益的 A 型肉毒毒素产品比抗体形成风险较低的产品更受欢迎。除了其美容用途外，肉毒毒素还用于多种皮肤状况。建议进行进一步的研究，以确定 A 型肉毒毒素在皮肤科治疗中的应用模式，如多汗症和酒渣鼻。
