关于支持人细胞膜结合型ACE2的必要性及反对可溶性ACE2对SARS-CoV-2感染性作用的证据的回应。 - Suppr

Response to Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.

作者信息

Yeung Man Lung, Teng Jade Lee Lee, Yuen Kwok-Yung

机构信息

State Key Laboratory of Emerging Infectious Diseases, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China.

State Key Laboratory of Emerging Infectious Diseases, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

出版信息

Cell. 2022 May 26;185(11):1840-1841. doi: 10.1016/j.cell.2022.05.005.

DOI:10.1016/j.cell.2022.05.005

PMID:35623328

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9134487/

Abstract

摘要

相似文献

Response to Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.关于支持人细胞膜结合型ACE2的必要性及反对可溶性ACE2对SARS-CoV-2感染性作用的证据的回应。

Cell. 2022 May 26;185(11):1840-1841. doi: 10.1016/j.cell.2022.05.005.

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.支持人细胞膜结合型血管紧张素转换酶2（ACE2）的必要性以及反对可溶性ACE2对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染性作用的证据。

Cell. 2022 May 26;185(11):1837-1839. doi: 10.1016/j.cell.2022.05.004.

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19.血管紧张素转换酶 2（ACE2）在 COVID-19 所致急性呼吸窘迫综合征发病机制中的作用。

Front Immunol. 2021 Dec 22;12:732690. doi: 10.3389/fimmu.2021.732690. eCollection 2021.

Coevolutionary forces shaping the fitness of SARS-CoV-2 spike glycoprotein against human receptor ACE2.塑造 SARS-CoV-2 刺突糖蛋白对人类受体 ACE2 适应性的协同进化力量。

Infect Genet Evol. 2021 Jan;87:104646. doi: 10.1016/j.meegid.2020.104646. Epub 2020 Nov 27.

Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation.ACE2 表达中的遗传变异性对 SARS-CoV-2 刺突 D614G 突变进化动态的影响。

Genes (Basel). 2020 Dec 24;12(1):16. doi: 10.3390/genes12010016.

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome.SARS-CoV-2 进入受体 ACE2 表达于造血和内皮细胞的非常小的 CD45 前体上，并且响应病毒刺突蛋白激活 Nlrp3 炎性小体。

Stem Cell Rev Rep. 2021 Feb;17(1):266-277. doi: 10.1007/s12015-020-10010-z.

Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent.截短的人血管紧张素转换酶2；一种潜在的严重急性呼吸综合征冠状病毒2刺突糖蛋白抑制剂和有效的2019冠状病毒病治疗剂。

J Biomol Struct Dyn. 2021 Jul;39(10):3605-3614. doi: 10.1080/07391102.2020.1768150. Epub 2020 May 20.

Noneffect of SARS-CoV-2 spike glycoprotein Y217N mutation on affinity between the virus and ACE2.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突糖蛋白Y217N突变对病毒与血管紧张素转换酶2（ACE2）亲和力的无影响。

J Biol Chem. 2021 Jan-Jun;296:100725. doi: 10.1016/j.jbc.2021.100725. Epub 2021 May 27.

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies.SARS-CoV-2 刺突蛋白与人 ACE2 受体相互作用的蛋白质结构分析：从构象变化到新型中和抗体。

Cell Mol Life Sci. 2021 Feb;78(4):1501-1522. doi: 10.1007/s00018-020-03580-1. Epub 2020 Jul 4.

Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding.竞争性 SARS-CoV-2 血清学研究表明，大多数针对刺突受体结合域的抗体竞争与 ACE2 结合。

mSphere. 2020 Sep 16;5(5):e00802-20. doi: 10.1128/mSphere.00802-20.

引用本文的文献

Facilitating and restraining virus infection using cell-attachable soluble viral receptors.利用细胞附着型可溶性病毒受体促进和抑制病毒感染。

Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2414583121. doi: 10.1073/pnas.2414583121. Epub 2024 Oct 31.

Uncovering the Role of -Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry.揭示糖基占据在刺突蛋白和血管紧张素转化酶 2 复合物协同组装中的作用：糖基工程和天然质谱的见解。

J Am Chem Soc. 2023 Apr 12;145(14):8021-8032. doi: 10.1021/jacs.3c00291. Epub 2023 Mar 31.

本文引用的文献

Cell. 2022 May 26;185(11):1837-1839. doi: 10.1016/j.cell.2022.05.004.

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.可溶性 ACE2 通过与肾素-血管紧张素系统相关蛋白的相互作用介导 SARS-CoV-2 的细胞进入。

Cell. 2021 Apr 15;184(8):2212-2228.e12. doi: 10.1016/j.cell.2021.02.053. Epub 2021 Mar 2.

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.MERS 冠状病毒通过上调 Smad7 和 FGF2 诱导肾和肺细胞凋亡。

Nat Microbiol. 2016 Feb 22;1(3):16004. doi: 10.1038/nmicrobiol.2016.4.

Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.严重急性呼吸综合征冠状病毒（SARS-CoV）的刺突蛋白和血管紧张素转换酶2（ACE2）对肿瘤坏死因子-α转换酶的调节可诱导肿瘤坏死因子-α的产生并促进病毒进入。

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14. doi: 10.1073/pnas.0711241105. Epub 2008 May 19.

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).肿瘤坏死因子-α转化酶（ADAM17）介导严重急性呼吸综合征冠状病毒（SARS-CoV）受体血管紧张素转换酶2（ACE2）的外显子结构域的调控性脱落。

J Biol Chem. 2005 Aug 26;280(34):30113-9. doi: 10.1074/jbc.M505111200. Epub 2005 Jun 27.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。