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Response to Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.

作者信息

Yeung Man Lung, Teng Jade Lee Lee, Yuen Kwok-Yung

机构信息

State Key Laboratory of Emerging Infectious Diseases, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China.

State Key Laboratory of Emerging Infectious Diseases, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

出版信息

Cell. 2022 May 26;185(11):1840-1841. doi: 10.1016/j.cell.2022.05.005.

DOI:10.1016/j.cell.2022.05.005
PMID:35623328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9134487/
Abstract
摘要

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本文引用的文献

1
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Cell. 2022 May 26;185(11):1837-1839. doi: 10.1016/j.cell.2022.05.004.
2
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.可溶性 ACE2 通过与肾素-血管紧张素系统相关蛋白的相互作用介导 SARS-CoV-2 的细胞进入。
Cell. 2021 Apr 15;184(8):2212-2228.e12. doi: 10.1016/j.cell.2021.02.053. Epub 2021 Mar 2.
3
MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.MERS 冠状病毒通过上调 Smad7 和 FGF2 诱导肾和肺细胞凋亡。
Nat Microbiol. 2016 Feb 22;1(3):16004. doi: 10.1038/nmicrobiol.2016.4.
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Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.严重急性呼吸综合征冠状病毒（SARS-CoV）的刺突蛋白和血管紧张素转换酶2（ACE2）对肿瘤坏死因子-α转换酶的调节可诱导肿瘤坏死因子-α的产生并促进病毒进入。
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14. doi: 10.1073/pnas.0711241105. Epub 2008 May 19.
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