塑造 SARS-CoV-2 刺突糖蛋白对人类受体 ACE2 适应性的协同进化力量。

Coevolutionary forces shaping the fitness of SARS-CoV-2 spike glycoprotein against human receptor ACE2.

机构信息

Department of Botany, Purnea Mahila College, Purnia, Bihar, India.

Department of Bioinformatics, Central University of South Bihar, Gaya, Bihar, India.

出版信息

Infect Genet Evol. 2021 Jan;87:104646. doi: 10.1016/j.meegid.2020.104646. Epub 2020 Nov 27.

DOI:10.1016/j.meegid.2020.104646

PMID:33249264

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7691136/

Abstract

The current global health problem caused by SARS-CoV-2 has challenged the scientific community in various ways. Therefore, worldwide several scientific groups are exploring SARS-CoV-2 from different aspects including its origin, spread, severe infectivity, and also to find a cure. It is now well known that spike glycoprotein helps SARS-CoV-2 to enter inside the human host through a cellular receptor ACE2. However, the role of coevolutionary forces that makes SARS-CoV-2 spike glycoprotein more fit towards its human host remains unexplored. Therefore, in present bioinformatics study we identify coevolving amino acids in spike glycoprotein. Additionally, the effects of coevolution on the stability of the spike glycoprotein as well as its binding with receptor ACE2 were predicted. The results clearly indicate that coevolutionary forces play a pivotal role in increasing the fitness of spike glycoprotein against ACE2.

摘要

当前由 SARS-CoV-2 引起的全球健康问题以各种方式挑战着科学界。因此，全球有几个科学小组从其起源、传播、严重传染性等方面探索 SARS-CoV-2，也在寻找治疗方法。现在人们已经清楚，刺突糖蛋白帮助 SARS-CoV-2 通过细胞受体 ACE2 进入人体宿主。然而，使 SARS-CoV-2 刺突糖蛋白更适应人类宿主的协同进化力量的作用仍未得到探索。因此，在目前的生物信息学研究中，我们确定了刺突糖蛋白中的共进化氨基酸。此外，还预测了共进化对刺突糖蛋白稳定性及其与受体 ACE2 结合的影响。结果清楚地表明，协同进化力量在提高刺突糖蛋白对 ACE2 的适应性方面起着关键作用。