丙酰去甲氧基安乃近与萘普生治疗髋骨关节炎的长期比较
A long-term comparison of proquazone and naproxen in the treatment of osteoarthritis of the hip.
作者信息
Vainio J T, Lepistö P V
出版信息
Scand J Rheumatol Suppl. 1978(21):25-7. doi: 10.3109/03009747809095671.
The efficacy and tolerance of 900 mg/day proquazone were compared with those of 500 mg/day naproxen in a three-month trial with 40 patients suffering from osteoarthritis of the hip. Proquazone was found to be more effective than naproxen in providing relief of symptoms and improving the patient's condition. The side effects of proquazone were exclusively gastrointestinal but occurred more frequently than with naproxen. With one exception, none of the symptoms were serious enough to require suspension of therapy. These results suggest that the action of proquazone provides a good balance between clinical efficacy and tolerance.
在一项针对40名髋骨关节炎患者的为期三个月的试验中，对每日服用900毫克丙氧苯酮的疗效和耐受性与每日服用500毫克萘普生的疗效和耐受性进行了比较。结果发现，丙氧苯酮在缓解症状和改善患者病情方面比萘普生更有效。丙氧苯酮的副作用仅为胃肠道反应，但比萘普生更频繁。除一例例外，所有症状均未严重到需要暂停治疗的程度。这些结果表明，丙氧苯酮的作用在临床疗效和耐受性之间达到了良好的平衡。
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