Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City 106335, Taiwan.
Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada.
Biosensors (Basel). 2022 Apr 28;12(5):286. doi: 10.3390/bios12050286.
Infectious diseases remain a pervasive threat to global and public health, especially in many countries and rural urban areas. The main causes of such severe diseases are the lack of appropriate analytical methods and subsequent treatment strategies due to limited access to centralized and equipped medical centers for detection. Rapid and accurate diagnosis in biomedicine and healthcare is essential for the effective treatment of pathogenic viruses as well as early detection. Plasma-engineered polymers are used worldwide for viral infections in conjunction with molecular detection of biomarkers. Plasma-engineered polymers for biomarker-based viral detection are generally inexpensive and offer great potential. For biomarker-based virus detection, plasma-based polymers appear to be potential biological probes and have been used directly with physiological components to perform highly multiplexed analyses simultaneously. The simultaneous measurement of multiple clinical parameters from the same sample volume is possible using highly multiplexed analysis to detect human viral infections, thereby reducing the time and cost required to collect each data point. This article reviews recent studies on the efficacy of plasma-engineered polymers as a detection method against human pandemic viruses. In this review study, we examine polymer biomarkers, plasma-engineered polymers, highly multiplexed analyses for viral infections, and recent applications of polymer-based biomarkers for virus detection. Finally, we provide an outlook on recent advances in the field of plasma-engineered polymers for biomarker-based virus detection and highly multiplexed analysis.
传染病仍然是对全球和公共卫生的普遍威胁，特别是在许多国家和城乡地区。由于缺乏适当的分析方法以及由于无法进入集中和配备医疗中心进行检测而导致的后续治疗策略，这些严重疾病的主要原因是缺乏适当的分析方法和后续治疗策略。在生物医学和医疗保健中快速准确的诊断对于有效治疗致病病毒以及早期检测至关重要。等离子体工程聚合物已在全球范围内用于结合生物标志物的分子检测来治疗病毒感染。基于等离子体聚合物的生物标志物病毒检测通常价格低廉，具有巨大的潜力。对于基于生物标志物的病毒检测，基于等离子体的聚合物似乎是潜在的生物探针，并已直接与生理成分一起使用，以同时进行高度多重分析。通过高度多重分析可以从同一样品体积中同时测量多个临床参数，从而检测人类病毒感染，从而减少收集每个数据点所需的时间和成本。本文综述了最近关于等离子体工程聚合物作为检测人类大流行病毒方法的功效的研究。在这项综述研究中，我们研究了聚合物生物标志物、等离子体工程聚合物、用于病毒感染的高度多重分析以及基于聚合物的生物标志物在病毒检测中的最新应用。最后，我们展望了基于等离子体工程聚合物的生物标志物病毒检测和高度多重分析领域的最新进展。
