Mousavi Seyyed Mojtaba, Hashemi Seyyed Alireza, Yari Kalashgrani Masoomeh, Omidifar Navid, Lai Chin Wei, Vijayakameswara Rao Neralla, Gholami Ahmad, Chiang Wei-Hung
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City 106335, Taiwan.
Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada.
Pharmaceuticals (Basel). 2022 Jul 17;15(7):880. doi: 10.3390/ph15070880.
The spread of viral diseases has caused global concern in recent years. Detecting viral infections has become challenging in medical research due to their high infectivity and mutation. A rapid and accurate detection method in biomedical and healthcare segments is essential for the effective treatment of pathogenic viruses and early detection of these viruses. Biosensors are used worldwide to detect viral infections associated with the molecular detection of biomarkers. Thus, detecting viruses based on quantum dots biomarkers is inexpensive and has great potential. To detect the ultrasensitive biomarkers of viral infections, QDs appear to be a promising option as biological probes, while physiological components have been used directly to detect multiple biomarkers simultaneously. The simultaneous measurement of numerous clinical parameters of the same sample volume is possible through multiplex detection of human viral infections, which reduces the time and cost required to record any data point. The purpose of this paper is to review recent studies on the effectiveness of the quantum dot as a detection tool for human pandemic viruses. In this review study, different types of quantum dots and their valuable properties in the structure of biomarkers were investigated. Finally, a vision for recent advances in quantum dot-based biomarkers was presented, whereby they can be integrated into super-sensitive probes for the multiplex detection of human viral infections.
近年来，病毒性疾病的传播引起了全球关注。由于病毒具有高传染性和易突变性，在医学研究中检测病毒感染已变得具有挑战性。在生物医学和医疗保健领域，一种快速准确的检测方法对于有效治疗致病病毒和早期发现这些病毒至关重要。生物传感器在全球范围内被用于检测与生物标志物分子检测相关的病毒感染。因此，基于量子点生物标志物检测病毒成本低廉且潜力巨大。为了检测病毒感染的超灵敏生物标志物，量子点作为生物探针似乎是一个很有前景的选择，同时生理成分已被直接用于同时检测多种生物标志物。通过对人类病毒感染的多重检测，可以在相同样本体积下同时测量众多临床参数，这减少了记录任何数据点所需的时间和成本。本文的目的是综述近期关于量子点作为人类大流行病毒检测工具有效性的研究。在这项综述研究中，研究了不同类型的量子点及其在生物标志物结构中的宝贵特性。最后，提出了基于量子点的生物标志物的最新进展展望，据此它们可被整合到用于人类病毒感染多重检测的超灵敏探针中。
