Mutru O, Penttilä M, Pesonen J, Salmela P, Suhonen O, Sonck T
Scand J Rheumatol Suppl. 1978(22):51-6. doi: 10.3109/03009747809097217.
In a double-blind crossover trial conducted on a multicentre basis, 109 patients with "classic" or "definite" rheumatoid arthritis were treated for two weeks with diclofenac sodium (Voltaren, 25 mg t.i.d.) and indomethacin (25 mg t.i.d). Both drugs led to a clear-cut decrease in morning stiffness, as well as to a significant improvement in pain at rest and on movement. In these respects no significant difference between the two-drugs was observed. As regards their effect on status of rheumatoid condition, however, a trend towards a significant improvement was discernible, in the investigator's opinion, only in response to diclofenac sodium. "Unwanted effects" were mentioned by 25 patients before the trial, by 31 during treatment with diclofenac sodium, and by 33 during treatment with indomethacin. While the patients were receiving indomethacin, five of them discontinued treatment on account of side effects (headache in three cases, headache and tiredness in one case, and an allergic skin reaction in one case) and one of them, who complained of headache, lowered the dosage; treatment with diclofenac sodium was discontinued because of side effects by only one patient, who had developed an allergic skin reaction.
在一项多中心双盲交叉试验中，109例“典型”或“确诊”类风湿性关节炎患者分别接受双氯芬酸钠（扶他林，25毫克，每日三次）和吲哚美辛（25毫克，每日三次）治疗两周。两种药物均使晨僵明显减轻，静息和活动时疼痛显著改善。在这些方面，两种药物未观察到显著差异。然而，就它们对类风湿病情状况的影响而言，在研究者看来，仅双氯芬酸钠有明显改善的趋势。试验前有25例患者提及“不良反应”，双氯芬酸钠治疗期间有31例，吲哚美辛治疗期间有33例。在患者接受吲哚美辛治疗时，其中5例因副作用停药（3例头痛，1例头痛伴疲倦，1例过敏性皮肤反应），1例抱怨头痛的患者减少了剂量；接受双氯芬酸钠治疗的患者中，只有1例因出现过敏性皮肤反应而停药。
