Valtonen E J
Scand J Rheumatol Suppl. 1978(22):69-73. doi: 10.3109/03009747809097220.
In a double-blind study, diclofenac sodium (Voltaren)--administered for 14 days in a dosage of 25 mg t.i.d.--was compared with naproxen (250 mg b.i.d. for 14 days) in the treatment of 120 patients with soft-tissue rheumatism. Assessment of the efficacy of the two treatments was based upon changes, recorded once a week, in the following parameters: pain at rest and on movement, swelling, local tenderness, functional impairment, limitation of movement, and sleep disturbances. The incidence of unwanted effects was also recorded, and the effects themselves were classified according to the probability of their being causally related to the trial preparations. Both drugs appeared to be effective in relieving symptoms associated with soft-tissue rheumatism. In most indications the therapeutic efficacy of the two preparations was similar. In patients suffering from diseases affecting the shoulder region, however, diclofenac sodium was significantly more effective. Unwanted effects rarely occurred with either drug.
在一项双盲研究中，将双氯芬酸钠（扶他林）以每日3次、每次25毫克的剂量给药14天，与萘普生（每日2次、每次250毫克，给药14天）用于治疗120例软组织风湿病患者进行比较。两种治疗方法疗效的评估基于以下参数每周记录一次的变化：静息和活动时的疼痛、肿胀、局部压痛、功能障碍、活动受限和睡眠障碍。还记录了不良反应的发生率，并根据不良反应与试验制剂存在因果关系的可能性对不良反应本身进行分类。两种药物似乎都能有效缓解与软组织风湿病相关的症状。在大多数指征中，两种制剂的治疗效果相似。然而，在患有影响肩部区域疾病的患者中，双氯芬酸钠的疗效明显更好。两种药物很少出现不良反应。
