Lu Yang, Zhang Ruiyang, Lei Hulong, Hang Yiqiong, Xue Huiqin, Cai Xuan, Lu Yonghong
Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
Animals (Basel). 2022 May 23;12(10):1329. doi: 10.3390/ani12101329.
The health status of weaned pigs is crucial for their subsequent growth performance. Supplementation with fermented feedstuff is able to improve the feed intake and growth of weaned pigs; however, the exact mechanism behind this is not clear. Hence, in the present study a total of 320 Duroc × Landrace × Yorkshire weaned pigs were selected and allocated to the following two groups: unfermented diet group (UFD) and fermented diet group (FD). The experimental period lasted 21 days. At the end of the experiment, feces, blood, and gastrointestinal tissue samples (including the stomach, jejunum, and ileum) were collected and used for further analysis. The results of growth performance suggested that the FD group had significantly increased (p < 0.05) average daily feed intake (ADFI) and average daily gain (ADG) during the first week, during the last two weeks, and over the entire three-week period compared with the UFD group. The results of the apparent nutrient digestibility of pigs showed that, compared with the UFD group, the FD group showed increased phosphorus (p < 0.05) and CP (p < 0.1) digestibility. There were no significant differences in the serum biochemical parameters between the UFD and FD groups. Moreover, our results showed that the FD group showed significantly increased gene expression of SGLT1 and PepT1 in the jejunum (p < 0.05). Compared with the UFD group, the FD group showed an increased (p < 0.05) serum orexin level and prepro-orexin (PPOX) expression in the gastric fundus, jejunum, and ileum mucosa and increased IGF-1 and IGFR expression in the jejunum. Collectively, these results indicated that supplementation with fermented feedstuff in the diet effectively enhanced the feed intake and growth of weaned pigs and that this may have been caused by the increased orexin, IGF-1, and IGFR serum levels.
断奶仔猪的健康状况对其后续生长性能至关重要。补充发酵饲料能够提高断奶仔猪的采食量和生长速度；然而，其背后的确切机制尚不清楚。因此，在本研究中，共选取了320头杜洛克×长白×大白断奶仔猪，并将其分为以下两组：未发酵日粮组（UFD）和发酵日粮组（FD）。实验期持续21天。实验结束时，收集粪便、血液和胃肠道组织样本（包括胃、空肠和回肠）用于进一步分析。生长性能结果表明，与UFD组相比，FD组在第一周、最后两周以及整个三周期间的平均日采食量（ADFI）和平均日增重（ADG）均显著增加（p<0.05）。猪的表观养分消化率结果表明，与UFD组相比，FD组的磷（p<0.05）和粗蛋白（p<0.1）消化率有所提高。UFD组和FD组之间的血清生化参数没有显著差异。此外，我们的结果表明，FD组空肠中SGLT1和PepT1的基因表达显著增加（p<0.05）。与UFD组相比，FD组胃底、空肠和回肠黏膜中的血清食欲素水平和前食欲素原（PPOX）表达增加（p<0.05），空肠中IGF-1和IGFR表达增加。总体而言，这些结果表明，日粮中补充发酵饲料可有效提高断奶仔猪的采食量和生长速度，这可能是由于血清食欲素、IGF-1和IGFR水平升高所致。
