Grau Marijke, Zollmann Emily, Bros Janina, Seeger Benedikt, Dietz Thomas, Noriega Ureña Javier Antonio, Grolle Andreas, Zacher Jonas, Notbohm Hannah L, Suck Garnet, Bloch Wilhelm, Schumann Moritz
Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
German Red Cross Blood Donation Service West, Center for Transfusion Medicine Hagen, Feithstraße 184, 58097 Hagen, Germany.
Biology (Basel). 2022 Apr 23;11(5):647. doi: 10.3390/biology11050647.
Autologous blood doping (ABD) refers to the transfusion of one's own blood after it has been stored. Although its application is prohibited in sports, it is assumed that ABD is applied by a variety of athletes because of its benefits on exercise performance and the fact that it is not detectable so far. Therefore, this study aims at identifying changes in hematological and hemorheological parameters during the whole course of ABD procedure and to relate those changes to exercise performance. Eight healthy men conducted a 31-week ABD protocol including two blood donations and the transfusion of their own stored RBC volume corresponding to 7.7% of total blood volume. Longitudinal blood and rheological parameter measurements and analyses of RBC membrane proteins and electrolyte levels were performed. Thereby, responses of RBC sub-populations-young to old RBC-were detected. Finally, exercise tests were carried out before and after transfusion. Results indicate a higher percentage of young RBC, altered RBC deformability and electrolyte concentration due to ABD. In contrast, RBC membrane proteins remained unaffected. Running economy improved after blood transfusion. Thus, close analysis of RBC variables related to ABD detection seems feasible but should be verified in further more-detailed studies.
自体血回输（ABD）是指将自身储存的血液进行回输。尽管其在体育赛事中被禁止使用，但据推测，由于其对运动表现有益且目前无法被检测到，仍有各类运动员会使用ABD。因此，本研究旨在确定ABD过程中血液学和血液流变学参数的变化，并将这些变化与运动表现相关联。八名健康男性进行了一项为期31周的ABD方案，包括两次献血以及回输相当于其总血容量7.7%的自身储存红细胞。对血液和流变学参数进行了纵向测量，并分析了红细胞膜蛋白和电解质水平。由此，检测到了红细胞亚群（从年轻红细胞到衰老红细胞）的反应。最后，在输血前后进行了运动测试。结果表明，由于ABD，年轻红细胞的比例更高，红细胞变形性和电解质浓度发生了改变。相比之下，红细胞膜蛋白未受影响。输血后跑步经济性得到改善。因此，对与ABD检测相关的红细胞变量进行仔细分析似乎是可行的，但应在进一步更详细的研究中加以验证。
