Sinitsyna Valentina V, Vetcher Alexandre A
Nanotechnology Scientific and Educational Center, Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia (RUDN), Miklukho-Maklaya St. 6, Moscow 117198, Russia.
Shirshov Institute of Oceanology, Russian Academy of Sciences 36, Nahimovskiy Prospect, Moscow 117997, Russia.
Biomedicines. 2022 May 6;10(5):1079. doi: 10.3390/biomedicines10051079.
Nucleic Acid (NA) aptamers are oligonucleotides. They are unique due to their secondary and tertiary structure; namely, the secondary structure defines the tertiary one by means of affinity and specificity. Our review is devoted only to DNA and RNA aptamers, since the majority of achievements in this direction were obtained with their application. NA aptamers can be used as macromolecular devices and consist of short single-stranded molecules, which adopt unique three-dimensional structures due to the interaction of complementary parts of the chain and stacking interactions. The review is devoted to the recent nanotechnological advances in NA aptamers application.
核酸（NA）适配体是寡核苷酸。它们因其二级和三级结构而独特；也就是说，二级结构通过亲和力和特异性来定义三级结构。我们的综述仅专注于DNA和RNA适配体，因为在这个方向上的大多数成果都是通过它们的应用获得的。NA适配体可用作大分子装置，由短单链分子组成，这些分子由于链的互补部分之间的相互作用和堆积相互作用而呈现独特的三维结构。这篇综述致力于NA适配体应用方面的最新纳米技术进展。
