Kayamba Violet, Kelly Paul
Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka P.O. Box 50398, Zambia.
Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Diagnostics (Basel). 2022 May 7;12(5):1160. doi: 10.3390/diagnostics12051160.
Early diagnosis of gastric cancer (GC) is compromised by a lack of specific signs to enable identification of affected individuals. We designed the Sanguis-filum (S-filum) as a simple bedside tool that could be used to detect the presence of gastric mucosal lesions prior to endoscopy. We previously published evidence that at a sensitivity of 91%, the presence of free blood in the stomach was associated with mucosal lesions. The S-filum is made of an inert but absorbent string coiled up in a gelatin capsule (Capsuline, FL, USA), which can be swallowed and the string retrieved to test for free blood. Preliminary testing of the S-filum was successfully conducted on healthy volunteers. We now intend to test it on actual patients, comparing the results to oesophagogastroduodenoscopy (OGD) findings. This will enable us to determine the diagnostic accuracy of the S-filum at detecting GC and other mucosal lesions. The S-filum as a bedside tool has the potential to assist healthcare providers to identify individuals likely to have early gastric mucosal lesions and requiring OGD examination. The S-filum could, in the long run, facilitate population-wide screening for early GC prior to endoscopy.
胃癌（GC）的早期诊断因缺乏能够识别受影响个体的特定体征而受到影响。我们设计了血丝（S-filum）作为一种简单的床边工具，可用于在内镜检查之前检测胃黏膜病变的存在。我们之前发表的证据表明，在灵敏度为91%的情况下，胃内游离血液的存在与黏膜病变相关。血丝由一根盘绕在明胶胶囊（Capsuline，美国佛罗里达州）中的惰性但有吸收性的细绳制成，该胶囊可被吞下，然后取出细绳检测游离血液。血丝已在健康志愿者身上成功进行了初步测试。我们现在打算在实际患者身上进行测试，并将结果与食管胃十二指肠镜检查（OGD）结果进行比较。这将使我们能够确定血丝在检测胃癌和其他黏膜病变方面的诊断准确性。血丝作为一种床边工具，有可能帮助医疗服务提供者识别可能患有早期胃黏膜病变且需要进行OGD检查的个体。从长远来看，血丝可以促进在内镜检查之前对人群进行早期胃癌筛查。
