Department of Anaesthesiology and Intensive Therapy, Silesian Centre for Heart Diseases in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Anesthesiology and Intensive Therapy, Provincial Specialist Hospital, 43-100 Tychy, Poland.
Int J Environ Res Public Health. 2022 May 12;19(10):5914. doi: 10.3390/ijerph19105914.
Analysis of patients with alcohol dependence (AD) treated in intensive care units has never been performed in Poland. Data from 25,416 adult patients identified in a Silesian Registry of Intensive Care Units were analysed. Patients with AD were identified, and their data were compared with the remaining population. Preadmission and admission variables that independently influenced ICU death in these patients were identified. Among 25,416 analysed patients, 2285 subjects (9.0%) were indicated to have AD among their comorbidities. Patients with AD were significantly younger (mean age: 53.3 ± 11.9 vs. 62.2 ± 15.5 years, p < 0.001) but had a higher mean APACHE II score at admission and were more frequently admitted to the ICU due to trauma, poisonings, acute pancreatitis, and severe metabolic abnormalities. ICU death and unfavourable outcomes were more frequent in these patients (47.8% vs. 43.0%, p < 0.001 and 54.1% vs. 47.0%, p < 0.001, respectively). Multiorgan failure as the primary cause of ICU admission was among the most prominent independent risk factors for ICU death in these patients (OR: 3.30, p < 0.001). Despite the younger age, ICU treatment of patients with AD was associated with higher mortality and a higher percentage of unfavourable outcomes.
在波兰，从未对重症监护病房（ICU）中治疗的酒精依赖（AD）患者进行过分析。对西里西亚重症监护病房登记处的 25416 名成年患者的数据进行了分析。确定了 AD 患者，并将其数据与其余人群进行了比较。确定了对这些患者 ICU 死亡有独立影响的入院前和入院变量。在分析的 25416 名患者中，2285 名患者（9.0%）存在 AD 合并症。AD 患者明显更年轻（平均年龄：53.3 ± 11.9 岁比 62.2 ± 15.5 岁，p < 0.001），但入院时的平均急性生理学与慢性健康状况评分Ⅱ（APACHE Ⅱ）更高，且因创伤、中毒、急性胰腺炎和严重代谢异常而更频繁地被收入 ICU。这些患者的 ICU 死亡和不良结局更为常见（47.8%比 43.0%，p < 0.001 和 54.1%比 47.0%，p < 0.001）。多器官衰竭作为 ICU 入院的主要原因，是这些患者 ICU 死亡的最显著独立危险因素之一（OR：3.30，p < 0.001）。尽管年龄较小，但 AD 患者的 ICU 治疗与更高的死亡率和更高比例的不良结局相关。
