State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Indian J Ophthalmol. 2021 May;69(5):1127-1134. doi: 10.4103/ijo.IJO_2858_20.
Aerobic exercise (AE) has been reported to decrease intraocular pressure (IOP) in healthy subjects and there are concomitant morphological changes in the anterior segment of the eye including the Schlemm's canal (SC). However, its effects on IOP and SC morphology in glaucoma patients had not been studied before. We aim to investigate the effect of AE on the IOP and SC dimension in both healthy and primary open-angle glaucoma (POAG) eyes.
The area and diameter of SC and IOP were measured in 35 primary open-angle glaucoma (POAG) patients (59 eyes) and 36 healthy subjects (72 eyes) before and after performing moderate intensity of AE by running on a treadmill for 30 min. SC was imaged by swept-source optical coherence tomography (SS-OCT) for evaluation.
In comparison with baseline values, mean IOP decreased significantly following AE in both POAG and healthy eyes (both P < 0.001), in which POAG eyes showed a greater degree of reduction compared to healthy eyes (P = 0.002). In comparison with baseline values, in both POAG and healthy eyes, the average cross-sectional area (POAG: 80.48 +/- 59.54 vs. 99.20 +/- 54.87 pixels; healthy: 151.84 +/- 52.76 vs. 198.23 +/- 53.70 pixels; both P < 0.001) and diameter (POAG: 3.73 +/- 1.69 vs. 4.33 +/- 1.74 pixels; healthy: 5.61 +/- 1.02 vs. 6.47 +/- 1.20 pixels; both P < 0.001) of SC significantly increased after AE. In POAG, both treated and untreated with IOP-lowering medications, a significant reduction in mean IOP and increase in SC dimensions following AE were observed (all P < 0.05), and there were no significant differences of such measurements between the two subgroups (all P > 0.05).
AE-induced reduction in IOP and an increase in SC dimensions in POAG eyes as in healthy eyes. Further studies to evaluate the long-term effect of AE on IOP control and SC morphology in POAG seem warranted.
有氧运动已被报道可降低健康受试者的眼内压（IOP），并且眼睛前段包括施莱姆氏管（SC）会出现相应的形态变化。然而，其对青光眼患者的 IOP 和 SC 形态的影响以前并未研究过。我们旨在研究有氧运动对健康人和原发性开角型青光眼（POAG）眼的 IOP 和 SC 尺寸的影响。
通过在跑步机上进行 30 分钟的中等强度有氧运动，在 35 名原发性开角型青光眼（POAG）患者（59 只眼）和 36 名健康受试者（72 只眼）之前和之后测量 SC 的面积和直径以及 IOP。使用扫频源光学相干断层扫描（SS-OCT）对 SC 进行成像以进行评估。
与基线值相比，POAG 和健康眼在进行有氧运动后，平均 IOP 均显著降低（均 P <0.001），POAG 眼的降低程度大于健康眼（P = 0.002）。与基线值相比，POAG 和健康眼的平均横截面积（POAG：80.48 ± 59.54 与 99.20 ± 54.87 像素；健康：151.84 ± 52.76 与 198.23 ± 53.70 像素；均 P <0.001）和直径（POAG：3.73 ± 1.69 与 4.33 ± 1.74 像素；健康：5.61 ± 1.02 与 6.47 ± 1.20 像素；均 P <0.001）在 SC 运动后均显著增加。在 POAG 中，无论是接受还是未接受降眼压药物治疗，有氧运动后平均 IOP 均显著降低，SC 尺寸均增加（均 P <0.05），并且两个亚组之间的这些测量值无显着差异（均 P > 0.05）。
POAG 眼和健康眼一样，有氧运动可降低 IOP 并增加 SC 尺寸。进一步研究评估有氧运动对 POAG 中 IOP 控制和 SC 形态的长期影响似乎是合理的。
