Ernberg Malin, Jasim Hajer, Wåhlén Karin, Ghafouri Bijar
Scandinavian Center for Orofacial Neuroscience (SCON), Department of Dental Medicine, Karolinska Institute, SE 141 04 Huddinge, Sweden.
Eastman Institute, Folktandvården Stockholms Län AB, SE 113 82 Stockholm, Sweden.
J Clin Med. 2022 May 14;11(10):2777. doi: 10.3390/jcm11102777.
The aims of this study were (1) to compare the levels and interactions of several plasma proteins in patients with myogenous temporomandibular disorders (TMDM) compared to healthy and pain-free controls, (2) to compare the levels and interactions in two TMDM subgroups, myalgia (MYA) and myofascial pain (MFP), and (3) to explore associations between the proteins and clinical data. Thirty-nine patients with TMDM (MFP, n = 25, MYA, n = 14), diagnosed according to the diagnostic criteria for TMD (DC/TMD), aged 38 years, and sex-matched pain-free controls completed an extended DC/TMD Axis II questionnaire and the plasma concentration of 87 biomarkers were analyzed. Nine proteins separated TMDM from controls (p = 0.0174) and 12 proteins separated MYA from MFP (p = 0.019). Pain duration, characteristic pain intensity, pain catastrophizing, perceived stress, and insomnia severity were significantly associated with protein markers (p < 0.001 to p < 0.022). In conclusion, several plasma proteins were upregulated in TMDM and either upregulated or downregulated in MYA compared to MFP. Some proteins in TMDM were associated with pain variables, sleep disturbance, and emotional function. These results show that systemic differences in protein expression exist in patients with TMDM and that altered levels of specific plasma proteins are associated with different clinical variables.
（1）比较肌源性颞下颌关节紊乱病（TMDM）患者与健康且无疼痛的对照组中几种血浆蛋白的水平及相互作用；（2）比较两个TMDM亚组，即肌痛（MYA）和肌筋膜疼痛（MFP）中的水平及相互作用；（3）探索这些蛋白与临床数据之间的关联。39例根据颞下颌关节紊乱病诊断标准（DC/TMD）诊断的TMDM患者（MFP组25例，MYA组14例），年龄38岁，以及性别匹配的无疼痛对照组完成了扩展的DC/TMD轴II问卷，并分析了87种生物标志物的血浆浓度。9种蛋白可将TMDM患者与对照组区分开（p = 0.0174），12种蛋白可将MYA与MFP区分开（p = 0.019）。疼痛持续时间、特征性疼痛强度、疼痛灾难化、感知压力和失眠严重程度与蛋白标志物显著相关（p < 0.001至p < 0.022）。总之，与MFP相比，几种血浆蛋白在TMDM中上调，在MYA中要么上调要么下调。TMDM中的一些蛋白与疼痛变量、睡眠障碍和情绪功能相关。这些结果表明，TMDM患者存在蛋白质表达的全身差异，特定血浆蛋白水平的改变与不同的临床变量相关。
