Sánchez Diana Carolina Villalpando, Castellanos Sergio Gutiérrez, Sandoval Martha Eva Viveros, García Anel Gómez
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México City 11340, Mexico.
Posgrado en Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México City 11340, Mexico.
Life (Basel). 2022 Apr 25;12(5):634. doi: 10.3390/life12050634.
Obesity (OB) is a major healthcare problem that results from long-term energy imbalance. Adipokines and pro-inflammatory cytokines facilitate adipose tissue (AT) remodeling to safely store excess nutrients. B-cell activating factor (BAFF) is a newly described adipokine whose role in enhancing adipogenesis has been reported. The present study aimed to evaluate serum BAFF association with adiposity distribution, serum adipokines, pro-inflammatory cytokines, and metabolic and endothelial dysfunction markers. The study included 124 young Mexican adults with no diagnosed comorbidities, divided according to their BMI. Anthropometric measurements, blood counts, and serum molecules (i.e., glucose, lipid profile, insulin, leptin, pro- and anti-inflammatory cytokines, von Willebrand factor (vWF), and BAFF) were assessed. The analysis showed positive correlation between BAFF and increased fat mass in all anthropometric measurements (p < 0.0001). BAFF augmentation was related to systemic inflammatory environment (p < 0.05), and linked with insulin resistance status (p < 0.05). BAFF increment was also correlated with early endothelial damage markers such as vWF (p < 0.0001). Linear regression analysis showed a role for BAFF in predicting serum vWF concentrations (p < 0.01). In conclusion, our data show that BAFF is an adipokine dynamically related to OB progression, insulin resistance status, and systemic inflammatory environment, and is a predictor of soluble vWF augmentation, in young overweight and obese Mexican subjects.
肥胖（OB）是一个主要的医疗保健问题，它是由长期能量失衡导致的。脂肪因子和促炎细胞因子促进脂肪组织（AT）重塑，以安全地储存多余的营养物质。B细胞活化因子（BAFF）是一种新描述的脂肪因子，其在增强脂肪生成中的作用已有报道。本研究旨在评估血清BAFF与肥胖分布、血清脂肪因子、促炎细胞因子以及代谢和内皮功能障碍标志物之间的关联。该研究纳入了124名未诊断出合并症的年轻墨西哥成年人，根据他们的BMI进行分组。评估了人体测量学指标、血细胞计数以及血清分子（即葡萄糖、血脂谱、胰岛素、瘦素、促炎和抗炎细胞因子、血管性血友病因子（vWF）和BAFF）。分析表明，在所有人体测量指标中，BAFF与脂肪量增加呈正相关（p < 0.0001）。BAFF升高与全身炎症环境相关（p < 0.05），并与胰岛素抵抗状态有关（p < 0.05）。BAFF升高还与早期内皮损伤标志物如vWF相关（p < 0.0001）。线性回归分析表明BAFF在预测血清vWF浓度方面发挥作用（p < 0.01）。总之，我们的数据表明，在年轻超重和肥胖的墨西哥受试者中，BAFF是一种与OB进展、胰岛素抵抗状态和全身炎症环境动态相关的脂肪因子，并且是可溶性vWF升高的预测指标。
