Kim So Young, Yoo Dae Myoung, Kim Ji Hee, Kwon Mi Jung, Kim Joo-Hee, Lee Jung Woo, Bang Woo Jin, Choi Hyo Geun
Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
Life (Basel). 2022 Apr 28;12(5):653. doi: 10.3390/life12050653.
The association of gout with nephrolithiasis has been suggested. The current study investigated the risk of nephrolithiasis in patients with gout. The relationship of nephrolithiasis with gout was assessed according to patient characteristics. Individuals in the Korean National Health Insurance Service−Health Screening Cohort were examined. The 17,043 participants with gout were paired with 68,172 comparison participants. The diagnosis of nephrolithiasis was examined in both the gout and control groups. The possible risk of nephrolithiasis in the gout group was analyzed using a stratified Cox proportional hazards model. Subcategory analyses were conducted according to demographic features and comorbidities. The rate of nephrolithiasis was 3.3% (569/17,043) in the gout group and 2.6% (1786/68,172) in the control group. The adjusted hazard ratio (aHR) of gout for nephrolithiasis was 1.23 (95% confidence intervals [95% CI] = 1.12−1.36) in the overall study population. The < 60 years and male groups showed an increased risk of nephrolithiasis related to gout (aHR = 1.26 [1.13−1.42] for the < 60 years group; aHR = 1.27 [1.15−1.41] for the male group). Regarding comorbidities, all subgroups except for the underweight, overweight, total cholesterol ≥ 240 mg/dL, fasting blood glucose ≥ 100 mg/dL, and CCI score 1 and ≥ 2 groups showed a higher risk of nephrolithiasis in gout patients. The gout patients presented an increased occurrence of nephrolithiasis. The middle-aged, male, and healthy populations showed consistently higher HRs of nephrolithiasis related to gout.
痛风与肾结石之间的关联已被提出。当前研究调查了痛风患者患肾结石的风险。根据患者特征评估了肾结石与痛风的关系。对韩国国民健康保险服务 - 健康筛查队列中的个体进行了检查。17043名痛风参与者与68172名对照参与者进行了配对。在痛风组和对照组中均对肾结石的诊断进行了检查。使用分层Cox比例风险模型分析痛风组中肾结石的可能风险。根据人口统计学特征和合并症进行了亚组分析。痛风组中肾结石的发生率为3.3%（569/17043），对照组中为2.6%（1786/68172）。在总体研究人群中，痛风患者患肾结石的调整后风险比（aHR）为1.23（95%置信区间[95%CI]=1.12 - 1.36）。年龄<60岁组和男性组显示与痛风相关的肾结石风险增加（年龄<60岁组的aHR = 1.26[1.13 - 1.42]；男性组的aHR = 1.27[1.15 - 1.41]）。关于合并症，除体重过轻、超重、总胆固醇≥240mg/dL、空腹血糖≥100mg/dL以及Charlson合并症指数（CCI）评分为1和≥2分组外，所有亚组中痛风患者患肾结石的风险均较高。痛风患者肾结石的发生率增加。中年、男性和健康人群显示与痛风相关的肾结石风险比始终较高。
