Chu Xin-Yi, Xu Yuan-Yuan, Tong Xin-Yu, Wang Gang, Zhang Hong-Yu
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.
Metabolites. 2022 May 20;12(5):461. doi: 10.3390/metabo12050461.
Adenosine triphosphate (ATP) may be the most important biological small molecule. Since it was discovered in 1929, ATP has been regarded as life's energy reservoir. However, this compound means more to life. Its legend starts at the dawn of life and lasts to this day. ATP must be the basic component of ancient ribozymes and may facilitate the origin of structured proteins. In the existing organisms, ATP continues to construct ribonucleic acid (RNA) and work as a protein cofactor. ATP also functions as a biological hydrotrope, which may keep macromolecules soluble in the primitive environment and can regulate phase separation in modern cells. These functions are involved in the pathogenesis of aging-related diseases and breast cancer, providing clues to discovering anti-aging agents and precision medicine tactics for breast cancer.
三磷酸腺苷（ATP）可能是最重要的生物小分子。自1929年被发现以来，ATP一直被视为生命的能量储备库。然而，这种化合物对生命的意义不止于此。它的传奇始于生命起源之时，一直延续至今。ATP必定是古代核酶的基本组成部分，可能促进了结构化蛋白质的起源。在现存生物中，ATP继续构建核糖核酸（RNA）并作为蛋白质辅因子发挥作用。ATP还作为一种生物增溶物质，它可能使大分子在原始环境中保持可溶状态，并能调节现代细胞中的相分离。这些功能与衰老相关疾病和乳腺癌的发病机制有关，为发现抗衰老药物和乳腺癌的精准医疗策略提供了线索。
