Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Heavy Ion Laboratory, University of Warsaw, Pasteura 5A, 02-093 Warsaw, Poland.
Molecules. 2022 May 21;27(10):3311. doi: 10.3390/molecules27103311.
Porphyrin ligands, showing a significant affinity for cancer cells, also have the ability to chelate metallic radioisotopes to form potential diagnostic radiopharmaceuticals. They can be applied in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to evaluate metabolic changes in the human body for tumor diagnostics. The aim of this paper is to present a short overview of the main metallic radionuclides complexed by porphyrin ligands and used in these techniques. These chelation reactions are discussed in terms of the complexation conditions and kinetics and the complex stability.
卟啉配体对癌细胞具有显著的亲和力，还能够螯合金属放射性同位素，形成潜在的诊断放射性药物。它们可应用于单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET），以评估人体代谢变化，从而进行肿瘤诊断。本文旨在简要概述与卟啉配体络合并应用于这些技术的主要金属放射性核素。本文从螯合条件和动力学以及配合物稳定性等方面讨论了这些螯合反应。
