Pascucci Ilaria, Paniccià Marta, Giammarioli Monica, Biagetti Massimo, Duranti Anna, Campomori Pamela, Smilari Valerio, Ancora Massimo, Scialabba Silvia, Secondini Barbara, Cammà Cesare, Lorusso Alessio
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche-Togo Rosati, 06126 Perugia, Italy.
Servizio Veterinario Sanità Animale Area Vasta 1-ASUR Marche, 61121 Pesaro, Italy.
Pathogens. 2022 Apr 26;11(5):514. doi: 10.3390/pathogens11050514.
Since the very beginning of the COVID-19 pandemic, SARS-CoV-2 detection has been described in several animal species. A total of 625 outbreaks in animals have been reported globally, affecting 17 species in 32 countries and the human source of infection has been recognized including pet owners, zookeepers, and farmers. In this report, we describe the case of a paucisymptomatic dog in Italy infected with SARS-CoV-2 from a household with three confirmed human cases of COVID-19 living in Pesaro (Marche region, Italy). The dog showed high viral RNA titers in the nasal and oropharyngeal swabs. In the nasal swab, SARS-CoV-2 RNA lasted for a least a week. By sequencing, the strain was assigned to the AY.23 lineage (PANGO), one of the sub-lineages of the major SARS-CoV-2 Delta variant of concern (VOC). Although we did not process the swabs of the three human cases, we strongly suspect a human origin for the dog infection. In this regard, AY.23 sequences, although never released thus far in the Marche region, were detected in the neighboring regions. Our findings highlight once more the need for a One Health approach for SARS-CoV-2 surveillance, management, and control, thus preventing viral spillover from animals to humans.
自新冠疫情伊始，就已在多种动物物种中发现了新冠病毒（SARS-CoV-2）。全球共报告了625起动物疫情，涉及32个国家的17个物种，且已确认感染源为人，包括宠物主人、动物园饲养员和农民。在本报告中，我们描述了意大利一只症状轻微的狗感染新冠病毒的病例，这只狗来自意大利佩萨罗（马尔凯大区）一户有三例新冠确诊病例的家庭。这只狗的鼻拭子和口咽拭子中显示出高病毒RNA滴度。在鼻拭子中，新冠病毒RNA至少持续了一周。通过测序，该毒株被归为AY.23谱系（PANGO），这是主要的新冠病毒变异株（VOC）德尔塔变体的一个亚谱系。尽管我们没有对这三例人类病例的拭子进行检测，但我们强烈怀疑这只狗的感染源是人。在这方面，虽然AY.23序列迄今尚未在马尔凯大区发布，但在邻近地区被检测到。我们的研究结果再次凸显了采用“同一健康”方法进行新冠病毒监测、管理和控制的必要性，从而防止病毒从动物传播给人类。
