Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Nutrients. 2022 May 10;14(10):1996. doi: 10.3390/nu14101996.
Exercise is a cornerstone in metabolic syndrome (MetS) treatment. However, the effects of low-volume exercise modalities on MetS-associated low-grade inflammation are unclear. A total of 106 MetS patients (53.7 ± 11.4 years) were randomized to low-volume high-intensity interval training (LOW-HIIT, 14 min/session), single-set resistance training (1-RT, ~15 min/session), whole-body electromyostimulation (WB-EMS, 20 min/session), three-set resistance training (3-RT, ~50 min/session), each performed 2 ×/week for 12 weeks, or a control group (CON). All groups received nutritional counseling for weight loss. Inflammatory and cardiometabolic indices were analyzed pre- and post-intervention. All groups significantly reduced body weight by an average of 3.6%. Only LOW-HIIT reduced C-reactive protein (CRP) (−1.6 mg/L, p = 0.001) and interleukin-6 (−1.1 pg/mL, p = 0.020). High-sensitivity CRP and lipopolysaccharide-binding protein decreased following LOW-HIIT (−1.4 mg/L, p = 0.001 and −2.1 ng/mL, p = 0.004) and 3-RT (−0.6 mg/L, p = 0.044 and −2.0 ng/mL, p < 0.001). MetS severity score improved with LOW-HIIT (−1.8 units, p < 0.001), 1-RT (−1.6 units, p = 0.005), and 3-RT (−2.3 units, p < 0.001). Despite similar effects on body weight, low-volume exercise modalities have different impact on inflammatory and cardiometabolic outcomes in MetS patients. LOW-HIIT has superior efficacy for improving inflammation compared to 1-RT and WB-EMS. Resistance-based exercise appears to require a higher volume to promote beneficial impact on inflammation.
运动是代谢综合征（MetS）治疗的基石。然而，低负荷运动方式对 MetS 相关低度炎症的影响尚不清楚。共有 106 名 MetS 患者（53.7±11.4 岁）被随机分为低负荷高强度间歇训练（LOW-HIIT，14 分钟/次）、单组抗阻训练（1-RT，15 分钟/次）、全身肌电刺激（WB-EMS，20 分钟/次）、三组抗阻训练（3-RT，50 分钟/次），每周 2 次，共 12 周，或对照组（CON）。所有组均接受减肥营养咨询。在干预前后分析了炎症和心血管代谢指标。所有组的体重平均减轻 3.6%。只有 LOW-HIIT 降低了 C 反应蛋白（CRP）（-1.6mg/L，p=0.001）和白细胞介素-6（-1.1pg/mL，p=0.020）。LOW-HIIT 和 3-RT 降低了高敏 C 反应蛋白和脂多糖结合蛋白（-1.4mg/L，p=0.001 和-2.1ng/mL，p=0.004 和-0.6mg/L，p=0.044 和-2.0ng/mL，p<0.001）。LOW-HIIT 降低了 MetS 严重程度评分（-1.8 分，p<0.001），1-RT（-1.6 分，p=0.005）和 3-RT（-2.3 分，p<0.001）。尽管对体重的影响相似，但低负荷运动方式对 MetS 患者的炎症和心血管代谢结果有不同的影响。LOW-HIIT 改善炎症的效果优于 1-RT 和 WB-EMS。基于阻力的运动似乎需要更高的运动量才能对炎症产生有益影响。
