Universidad de Alcalá, Facultad de Medicina y Ciencias de la Salud, Departamento de Ciencias Biomédicas, Área de Educación Física y Deportiva, 28871 Madrid, Spain.
Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Int J Environ Res Public Health. 2021 Dec 16;18(24):13258. doi: 10.3390/ijerph182413258.
Low-grade systemic inflammation leads to critical alterations of several tissues and organs that can promote the appearance of non-communicable diseases, a risk that is increased in adults with obesity. Exercise training may counteract low-grade systemic inflammation, but there is a lack of consensus on how cytokines are modulated by training in adults with obesity. This study aimed of examining the effects of exercise training on circulating pro- and anti-inflammatory cytokines in adults with overweight and obesity, and whether exercise-induced fat mass reduction could mediate that effect. The search was conducted on Medline (Pubmed), SPORTDiscus and Web of Science databases from January 1998 to August 2021, using keywords pertaining to inflammation, exercise, and obesity. A total of 27 studies were selected, in which the circulating concentration levels of cytokines were analyzed. Endurance training (ET) decreased circulating CRP, IL-6 and TNF-α levels. TNF-α was reduced after resistance and concurrent training (CT), while IL-10 increased after resistance training (RT). Changes in IL-10 and CRP coincided with fat mass reduction, while decreased TNF-α levels were concomitant with changes in IL-6 and IL-10. Exercise training may reduce systemic low-grade inflammation profile in adults with overweight and obesity.
低度全身炎症会导致多个组织和器官发生严重改变，从而增加非传染性疾病的风险，而肥胖成年人的这种风险更高。运动训练可能会对抗低度全身炎症，但对于肥胖成年人的训练如何调节细胞因子，目前还没有共识。本研究旨在探讨运动训练对超重和肥胖成年人循环中促炎和抗炎细胞因子的影响，以及运动引起的脂肪量减少是否可以介导这种作用。从 1998 年 1 月至 2021 年 8 月，我们在 Medline（Pubmed）、SPORTDiscus 和 Web of Science 数据库中使用与炎症、运动和肥胖相关的关键词进行了搜索。共选择了 27 项研究，分析了细胞因子的循环浓度水平。耐力训练（ET）降低了循环 CRP、IL-6 和 TNF-α 水平。抗阻和综合训练（CT）后 TNF-α 降低，而抗阻训练（RT）后 IL-10 增加。IL-10 和 CRP 的变化与脂肪量减少相一致，而 TNF-α 水平的降低与 IL-6 和 IL-10 的变化同时发生。运动训练可能会降低超重和肥胖成年人的全身低度炎症状态。
