Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, National Engineering Research Center for Fruit and Vegetable Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Nutrients. 2022 May 10;14(10):1994. doi: 10.3390/nu14101994.
Resveratrol (RSV), a natural polyphenol, has been shown to exert activity against obesity and related chronic inflammation. However, due to the poor bioavailability of RSV, the mechanisms of RSV against inflammation in obesity models remain unclear. In this study, we aimed to investigate the relationship between the gut bacteria and the anti-inflammation effects of RSV in HFD-fed mice. We found that RSV supplementation reduced fat accumulation and improved systemic inflammation in HFD-fed mice. Meanwhile, RSV attenuated HFD-induced changes in the gut microbiota's structure, which were associated with inflammatory parameters. A fecal microbiota transplantation (FMT) experiment proved that the anti-inflammation effects of RSV largely rely on the gut microbiota. Moreover, the microbiota-genera-changing trend in the FMT experiment was similar to that in the oral RSV-feeding experiment. Thus, these results demonstrate that modulation of the gut bacteria induced by RSV treatment has a therapeutic effect on chronic low-grade inflammation in HFD-fed mice.
白藜芦醇（RSV）是一种天然多酚，已被证明具有抗肥胖和相关慢性炎症的作用。然而，由于 RSV 的生物利用度较差，其在肥胖模型中抗炎的机制仍不清楚。在本研究中，我们旨在探讨肠道细菌与 RSV 在高脂饮食喂养小鼠中的抗炎作用之间的关系。我们发现 RSV 补充剂可减少 HFD 喂养小鼠的脂肪堆积并改善全身炎症。同时，RSV 减轻了 HFD 诱导的肠道微生物组结构的变化，这些变化与炎症参数有关。粪便微生物群移植（FMT）实验证明 RSV 的抗炎作用在很大程度上依赖于肠道微生物群。此外，FMT 实验中的微生物群属变化趋势与口服 RSV 喂养实验相似。因此，这些结果表明，RSV 治疗诱导的肠道细菌调节对 HFD 喂养小鼠的慢性低度炎症具有治疗作用。
