Wei Qiang, Fu Guoqiang, Wang Ke, Yang Qiong, Zhao Jiarui, Wang Yuan, Ji Kai, Song Shuliang
Marine College, Shandong University, Weihai 264209, China.
Weihaiwei People's Hospital, Weihai 264200, China.
Pharmaceuticals (Basel). 2022 May 6;15(5):581. doi: 10.3390/ph15050581.
In recent years, various viral diseases have suddenly erupted, resulting in widespread infection and death. A variety of biological activities from marine natural products have gradually attracted the attention of people. Seaweeds have a wide range of sources, huge output, and high economic benefits. This is very promising in the pharmaceutical industry. In particular, sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body's immunity. This review focuses on recent advances in antiviral research on the sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan. We hope that this review will provide new ideas for the development of COVID-19 therapeutics and vaccines.
近年来，各种病毒性疾病突然爆发，导致广泛感染和死亡。海洋天然产物的多种生物活性逐渐引起人们的关注。海藻来源广泛、产量巨大且经济效益高。这在制药行业极具前景。特别是来自海藻的硫酸化多糖，被认为是药物开发中生物活性化合物的潜在来源，已显示出对多种病毒具有抗病毒活性，主要包括常见的DNA病毒和RNA病毒。此外，硫酸化多糖还可以提高机体免疫力。本综述重点关注海藻硫酸化多糖抗病毒研究的最新进展，包括卡拉胶、半乳聚糖、岩藻聚糖、藻酸盐、褐藻糖胶、p-KG03、舟形藻多糖和螺旋藻钙。我们希望本综述能为COVID-19治疗药物和疫苗的开发提供新思路。
