University of Coimbra, MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Department of Life Sciences, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.
Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.
Mar Drugs. 2023 Apr 23;21(5):261. doi: 10.3390/md21050261.
Polyphenols are beneficial natural compounds with antioxidant properties that have recently gain a lot of interest for their potential therapeutic applications. Marine polyphenols derived from marine macroalgae have been discovered to possess interesting antioxidant properties; therefore, these compounds can be included in several areas of drug development. Authors have considered the use of polyphenol extracts from seaweeds as neuroprotective antioxidants in neurodegenerative diseases. Marine polyphenols may slow the progression and limit neuronal cell loss due to their antioxidant activity; therefore, the use of these natural compounds would improve the quality of life for patients affected with neurodegenerative diseases. Marine polyphenols have distinct characteristics and potential. Among seaweeds, brown algae are the main sources of polyphenols, and present the highest antioxidant activity in comparison to red algae and green algae. The present paper collects the most recent in vitro and in vivo evidence from investigations regarding polyphenols extracted from seaweeds that exhibit neuroprotective antioxidant activity. Throughout the review, oxidative stress in neurodegeneration and the mechanism of action of marine polyphenol antioxidant activity are discussed to evidence the potential of algal polyphenols for future use in drug development to delay cell loss in patients with neurodegenerative disorders.
多酚是具有抗氧化特性的有益天然化合物，最近因其潜在的治疗应用而受到广泛关注。从海洋大型藻类中提取的海洋多酚被发现具有有趣的抗氧化特性；因此，这些化合物可以应用于药物开发的多个领域。作者已经考虑将海藻多酚提取物用作神经退行性疾病中的神经保护抗氧化剂。由于其抗氧化活性，海洋多酚可以减缓进展并限制神经元细胞丢失；因此，使用这些天然化合物可以提高受神经退行性疾病影响的患者的生活质量。海洋多酚具有独特的特性和潜力。在海藻中，褐藻是多酚的主要来源，其抗氧化活性高于红藻和绿藻。本文收集了关于具有神经保护抗氧化活性的海藻多酚提取物的最新的体外和体内研究证据。在综述过程中，讨论了神经退行性变中的氧化应激和海洋多酚抗氧化活性的作用机制，以证明藻类多酚在未来用于开发药物以延缓神经退行性疾病患者的细胞损失方面的潜力。
